Education of TEPs is conducted through direct (face-to-face) and indirect (virtual) interactions with tumor cells.TEPs circulate throughout the body of cancer patients and play pivotal roles in promotion of tumor growth and dissemination.Platelets' transcriptome in cancer patients demonstrates ...
Tumor-educated platelets (TEPs) as a liquid biopsy biosource Liquid biopsies could provide a potential revolution in cancer diagnostics as a minimally invasive method for detecting and monitoring cancer. Liquid biopsies may provide an accurate and comprehensive snapshot of the tumor and its microenviron...
The changes of TEPs profile represent a massive, concentrated biorepository of tumor-derived and bioactive molecules, indicating the potential of TEPs as specific biomarkers for cancer. Due to the short lifespan and the structure of platelet membrane, tumor-specified biosources and biomolecules are enr...
detection Shanshan Ding1†, Xiaohan Dong2† and Xingguo Song1* Abstract Platelets, involved in the whole process of tumorigenesis and development, constantly absorb and enrich tumor- specific substances in the circulation during their life span, thus called "Tumor Educated Platelets" (TEPs...
Biomarkers in the blood of cancer patients include circulating tumor cells (CTCs), tumor‐educated platelets (TEPs), tumor‐derived extracellular vesicles (tdEVs), EV‐associated miRNA (EV‐miRNA), and circulating cell‐free DNA (ccfDNA). Because the size and density of biomarkers differ, blood ...
These interactions educate platelets causing changes in their gene expression leading to development of tumor educated platelets (TEPs). Consequently, these TEPs exhibit altered function and can promote tumor cell survival and metastasis. Previous studies have demonstrated that transcriptomic analysis of ...
It has been reported that tumor-educated platelets (TEPs) may enable blood-based cancer diagnostics. Platelets have emerged as central players in the systemic and local responses to tumor growth. Confrontation of platelets with tumor cells via transfer of tumor-associated biomolecules ("education") ...
Tumor-educated platelets (TEPs) have emerged as a promising liquid biopsy biosource for the detection of various cancer types. In this study, we processed and analyzed the TEPs collected from 466 Non-small Cell Lung Carcinoma (NSCLC) patients and 410 asymptomatic individuals (controls) using the...
METHODS. Wild-type platelets (WTPs) were isolated from blood of healthy humans or mice, whereas tumor-educated platelets (TEPs) were isolated from blood of breast cancer patients or from tumor-bearing donor mice. The tumorigenic and modulatory effect of these two types of platelets on breast ...
Tumor-educated platelets (TEPs) are potential biomarkers for cancer diagnostics. We employ TEP-derived RNA panels, determined by swarm intelligence, to detect and monitor glioblastoma. We assessed specificity by comparing the spliced RNA profile of TEPs from glioblastoma patients with multiple sclerosis ...