This reflects PDTOs are expected to become the next generation of preclinical tumor research models which are worth replicating. Urological PDTO biobanks Kidney tumors are one of the most common solid tumors in children and lack preclinical research models that capture tumor heterogeneity. The PDTO...
The cross-sections of tumor tissue (A) and normal tissue (B) are shown in cartoons, respectively. Cells within tumor tissues experience solid mechanical stress from the structural components and interstitial fluid pressure (IFP). The upper-left quarter of (A) and (B) shows the solid stress d...
1). The key enzyme in glutamine metabolism is glutaminase (GLS), which can effectively convert glutamine to glutamate. Two distinct isoforms of GLS have been reported so far: The GLS in kidney (GLS1) is commonly expressed in various normal tissues, whereas the GLS in liver (GLS2) is ...
All mice were dissected post-treatment, the tumors / major organs were collected for further biosafety evaluation of materials and the efficacy of PTT. H&E staining was performed for main organs mainly including heart, liver, spleen, lung, and kidney. Fluorescent TUNEL staining was performed accor...
Normal tissue samples (liver, lymph node, kidney, spleen) were obtained from research colony dogs at Colorado State University. Two normal organs were used for each tissue type. Tissues were sectioned and flash frozen. The Institutional Animal Care and Use Committee reviewed collection protocols. ...
After treatment, the mice were sacrificed and their main organs, such as heart, liver, spleen and kidney, were harvested, sliced, and stained with hematoxylin and eosin (H&E) for histopathological toxicity analysis (Fig. S1). No anatomic changes were found, suggesting no obvious toxic effect ...
Called 20P1F12 / TMPRSS2, is based on it usually, or is derived from the secretion serine protease of cell membrane-bound, which is androgen-regulated prostate-specific, composition for the treatment and diagnosis of kidney cancer bladder cancer, lung cancer, and ovarian cancer, I disclose thi...
While DNA was traditionally thought to be stable, with individual genomes set at the time of fertilization, recent evidence demonstrates that humans are genomic mosaics, comprised of cells that are genetically distinct even though they were derived from a single zygote [2]. Cancer is one of the...
Mouse tumor cell lines MC38 (colon cancer) and E0771 (breast cancer), the mouse embryonic fibroblast cell line NIH-3T3, the human tumor cell line HCT116 (colon cancer) and the human embryonic kidney cell line HEK 293T were purchased from the China Center for Type Culture Collection and we...
The distant metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of the tumor cells and extrinsic factors in their microenvironment. During an intermediate stage of metastasis, circulating tumor cells (CTCs) are released into the bloodstream from primary and ...