The tumor cells are positive for synaptophysin, chromogranin, CDX2, and ER (weak); and negative for CK7 and GATA3. These immunophenotypic features, in conjunction with the clinical history and cellular morpholog
Immunohistochemistry was positive for synaptophysin, chromogranin, CD117 and CK with high Ki 67, proliferative Index of >90% consistent with high grade neuroendocrine tumor. The tumor cells were negative for CD-45 (Fig. 8). Subsequently, the patient underwent 3 cycles of adjuvant chemotherapy inclu...
curated RNA signatures that denote either tissue lineage or cancer-specific transcripts within the background of normal blood cells. Of note, GU-1 CTCs express multiple neuroendocrine genes (CHGA, SYP, and DLL3), consistent with immunohistochemistry staining for synaptophysin and chromogranin A in a...
The tumor cells were positive for S-100 protein, SOX10, and vimentin in 100% of cases, for CD56 in 70%, for synaptophysin in 56%, for NB84 in 50%, for NSE in 45%, and for neurofilament protein in 14% of cases. All cases tested were negative for specific melanocytic, ...
Extracellular vesicles (EVs), nanoscale vesicles secreted by cells, have attracted considerable attention in recent years due to their role in tumor immunomodulation. These vesicles facilitate intercellular communication by transporting proteins, nucleic
Immunohistochemical staining revealed globoid perinuclear positivity for desmin. Vimentin, cytokeratin (AE3, CaM 5.2), epithelial membrane antigen, tissue polypeptide antigen, neuron‐specific enolase, chromogranin A, endocrine granule constituent and synaptophysin were also positive in the cytoplasm. Electron...
Extracellular vesicles (EVs), nanoscale vesicles secreted by cells, have attracted considerable attention in recent years due to their role in tumor immunomodulation. These vesicles facilitate intercellular communication by transporting proteins, nucleic
Immuno- histochemically, these tumor cells are positive for neuron-specific enolase (NSE) and human melanoma black 45 (HMB-45), but negative for myogenic markers (α-smooth muscle actin (α-SMA) and HHF-35), epithe- lial markers (AE1/AE3, CAM5.2), endocrine markers (synaptophysin, ...
3d). Immunohistochemically, the tumor cells were positive for trypsin and negative for chromogranin A, synaptophysin, and CD56 (Figs. 3e, f, g, and h). The resected margins were free of tumor cells. Although residual ectopic pancreas was not identified, the tumor was diagnosed as pancreatic-...
3C). Immunohistochemically, the tumor cells were positive for synaptophysin (Fig. 3D), chromogranin, and CD56. The Ki-67 labeling index was 4.4% in the hotspot (Fig. 3E). Download: Download high-res image (776KB) Download: Download full-size image Fig. 1. Treatment of a rectal ...