Immunohistochemistry was positive for synaptophysin, chromogranin, CD117 and CK with high Ki 67, proliferative Index of >90% consistent with high grade neuroendocrine tumor. The tumor cells were negative for CD-45 (Fig. 8). Subsequently, the patient underwent 3 cycles of adjuvant chemotherapy inclu...
Clear intracytoplasmic vacuoles were seen within the tumor cells. These tumor cells were immunopositive for synaptophysin, NSE, and MAP-2, confirming their neurocytic origin. On ultrastructural examination, lipid vacuoles as well as dense-core neurosecretory granules were identified within these neuro...
The tumors cells showed medium to large hyperchromatic nuclei with coarse granular chromatin, occasional nucleoli, small to moderate amphophillic cytoplasm, and scattered mitotic figures (HE, ×40); C: The tumor cells were strongly positive for synaptophysin (×40); D: 5% of the tumor cells ...
T cells with positive Ki-67 nuclear expression were proliferating, and PD-1 positivity denoted PD-1+ T cells. Expression of synaptophysin identified tumor cells. (B) Quantification of CD4+ T cell, CD8+ T cell, and Treg cell density (cells per mm2), as well as proliferating and PD-1+ ...
there is lack of effective treatment for chronic stress in cancer patients. In this review, we discuss the main mechanisms by which chronic stress regulates the tumor microenvironment, including functional regulation of tumor cells by stress hormones (stem cell-like properties, metastasis, angiogenesis...
Immunohistochemistry staining showed that tumor cells were positive for cytokeratin, SALL4, glypican-3, focal positive for EMA, vimentin, CD10, and CD34, but negative for a-fetoprotein, HCG, PLAP. The serum α-fetoprotein was 664.60 ng/mL (normal, ≤25 ng/mL). Yolk sac tumor of the ear...
Immunohistochemical studies revealed that the tumor cells were positive for chromogranin, CD56 and synaptophysin, while they were negative for S-100, cytokeratin (CK)-5/6 and p63. Mib-1 labeling index was 50%. These findings were diagnostic markers of high-grade neuroendocrine carcinoma. Discuss...
a small, yellow tumor that may develop from argentaffin cells in the gastrointestinal mucosa and spread widely throughout the body. See also:Cancer -Ologies & -Isms. Copyright 2008 The Gale Group, Inc. All rights reserved. ThesaurusAntonymsRelated WordsSynonymsLegend: ...
Carcinoid tumor, as the glomus tumor, can show an organoid pattern, increased vascularity, and uniform, round cells with eosinophilic cytoplasm, but usually are positive for cytokeratin and always stained with chromogranin and synaptophysin showing negative for smooth muscle markers which is presented in...
Endolymphatic Sac Tumor (Aggressive Papillary Tumor of the Temporal Bone and Ear, Low-Grade Adenocarcinoma, Aggressive Papillary Middle Ear Tumor, von Hippel-Lindau Disease) Clinical Features In 1988, Gaffey and colleagues302 reported 10 cases (one of their own and nine cases from a literature revi...