The tumor cells were large sized and form irregular nests embedded in abundant desmoplastic stroma. Immunohistochemically, the tumor cells were positive for cytokeratin, GATA3, p40, and p63. Working differential diagnosis included squamous cell carcinoma, myoepithelial carcinoma, ...
Hsa-miR-196a2*, the most highly estrogen up-regulated miRNA, markedly down-regulated tumor protein p63 (TP63), a member of the p53 family. In ERα-positive and ERα-negative breast cancer cells, proliferative and invasiveness ... Kyuri,Kim,Zeynep,... - 《Hormones & Cancer》 被引量: ...
However, there are several obstacles that CTCs must overcome in order to successfully detach from the primary tumor tissue, including: 1) Adhesion: Extracellular matrix (ECM) and surrounding cells in the tissue of the primary tumor are both firmly adhered to by cancer cells, which are typically ...
Thus, p63 deficiency can evoke cellular senescence both in vivo and in cultured cells. A separate study also implicates p63 as a regulator of aging. The Sidransky group reported that transgenic mice that express ΔNp63α under the control of keratin14 (K14) promoter displayed an aging ...
30.29A). As their cell of origin suggests, these lesions are positive for p63 (strongest in the vacuolated cells) and inhibin (strongest in the maturing cells) (see Fig. 30.29B and C); however, unlike their malignant counterpart, ETT, the proliferation index is below 10% and will be ...
Transcriptional repression of miR-34 family contributes to p63-mediated cell cycle progression in epidermal cells. J Invest Dermatol 2010; 130: 1249–57. CAS PubMed Google Scholar Noonan EJ, Place RF, Basak S, Pookot D, Li LC . miR-449a causes Rb-dependent cell cycle arrest and ...
The cells have moderate-to-high N : C ratios and may contain a few discrete cytoplasmic vacuoles. Nuclei are generally round and centrally or basally located, with variably distinct nucleoli. Cytologically, renal carcinomas may be mistaken for neuroendocrine tumors. Pulmonary Carcinomas or ...
when presenting nuclear stain in more than 5% of tumor cells for anti-ER and anti-PR antibodies [28]; when presenting nuclear stain in more than 10% of tumor cells for anti-p63 antibody [29]. Molecular taxonomy The application of the panel allowed cases to be grouped into five molecular ...
(thus, positive for CK7, CK18, and CK19) whereas the outer layer has a basal phenotype and is positive for high molecular weightkeratins(ie, CK5/6) and p63.106,107Similar to the abluminal cells of striated ducts, the outer layer of Warthin tumor epithelium shows rare to absent myo...
Lack of p63 and WT-1 in calponin positive myoepithelial cells A set of four adjacent sections were immunostained for calponin and mapin, p63, and WT-1. Arrows identify myoepithelial cell layers. Note that in a hyperplastic duct, a number of myoepithelial cells lack p63 and WT-1 expression...