Mesenchymal Stromal Cells as Tumor Stromal ModulatorsWalker ND, N. G., MUnoz J, Lucas J, Pobiarzyn, P, Rameshwar P. (2016) Mesenchymal Stem/Stromal Cells and the Tumor Immune System. in Mesenchymal Stromal Cells as Tumor Stromal Modulators, Elsevier, San Diego, CA. pp 425-447...
There is evidence that the immune system controls the development of cancer; that is, immune surveillance against neoplasia is operating in normal animals [1]. Substantial evidence also exists showing that cancer patients harbor T cells reactive with their own cancer cells [2]. Tumor immune surveil...
Most T cells in tumor microenvironment are exhausted, leading to cancer immune evasion. PD-1 is the major inhibitory receptor regulating T-cell exhaustion, T cells with high PD-1 expression lose the ability to eliminate cancer. Reversing T-cell exhaustion represents an inspiring strategy to treat...
The cancer immunoediting hypothesis postulates a dual role of the immune system: protecting the host by eliminating tumor cells, and shaping the tumor by editing its genome. Here, we elucidate the impact of evolutionary and immune-related forces on editing the tumor in a mouse model for hypermuta...
tumor cells. While in vitro immune cell killing is recognized as perhaps one of the most relevant functional measures to evaluate the ability of candidate compounds or antibodies in promoting the effector immune function, many techniques have been developed and appropriate in vitro assays for the ...
Tang and Zheng Cell Biosci (2018) 8:34 https://doi.org/10.1186/s13578-018-0232-4 Cell & Bioscience RESEARCH HIGHLIGHT Open Access Tumor cells versus host immune cells: whose PD‑L1 contributes to PD‑1/PD‑L1 blockade mediated cancer immunotherapy? Fei Tang* and...
As the essential sexual hormone, estrogen and its receptor has been proved to participate in the regulation of autoimmunity diseases and anti-tumor immunity. The adjustment of tumor immunity is related to the interaction between cancer cells, immune cell
Spatial imaging reveals compartmentalization of tumor and immune cells Solid tumors are composed of tumor cells, immune cells, stromal cells, and a vascular system. These components are not evenly distributed. Tumor cell-rich and stroma-rich areas are evident under traditional histological examination....
The immune system plays an essential role in the tumor progression; not only can it inhibit tumor growth but it can also promote tumor growth by establishing a favorable environment. Tumor cells utilize several strategies to evade the host's immune system, including expression of immunosuppressive ...
There is considerable evidence for the role of immune cells in the resistance of the host to tumor growth. The chapter discusses the possible role of assays in the diagnosis, prognosis, and therapy of cancer.References (371) B.R. Bloom Advan. Immunol. (1971) K. Borum et al. Cell. ...