The most commonly used animal cell lines for PNETs studies are rat insulinoma cell lines (RINs), employed to study the expression of the tumor suppressor gene TP53 in PNETs [41]. Besides these cells, INS1, MIN6, and βTC3 cell lines are commonly used, and SSTR2 are known to be ...
The somatostatin receptor subtype sst2 mediates both activation of a tyrosine phosphatase activity and inhibition of cell proliferation induced by somatostatin analogues. In the absence of exogenous ligand, expression of sst2 in NIH 3T3 cells resulted in inhibition of cell growth. Polymerase chain ...
The functional implications of de novo expression of L1CAM in cancer-associated vessels are not limited to the tumor-endothelial crosstalk. Indeed, vascular L1CAM exerts a cell-autonomous role in ECs. By combining a mouse model of L1CAM-negative pancreatic carcinoma with the endothelial...
Methylation of the EGFR promoter inhibits EGFR expression in a variety of tumor cells. Three NSCLC cell lines (H1650, H1299 and PC-9) with different EGFR mutation statuses and levels of EGFR-TKI sensitivity were used in this study. The results showed that the EGFR prom...
A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function. Preferr
For cervical cancer, Merkel cell carcinoma, occult cervical (head and neck) metastases, penile cancer, uterine neoplasms (endometrial cancer and uterine sarcoma), and vulvar cancer; For members with ductal carcinoma in-situ (DCIS) when one of the following criteria is met: Member is undergoing ...
Development of long-term cell lines and lymphoid clones reactive against murine and human tumors: a new approach to the adoptive immunotherapy of cancer. Surgery. 1982;92:328–36. PubMed CAS Google Scholar Gaugler B, Van den Eynde B, van der Bruggen P, Romero P, Gaforio JJ, De Pla...
Inhibition of tumor promoting signals by activa- tion of SSTR2 and opioid receptors in human breast cancer cells. Cancer Cell Int 2013; 13: 93.Kharmate G, Rajput PS, Lin YC, Kumar U (2013). Inhibition of tumor promot- ing signals by activation of SSTR2 and opioid receptors in human ...
Somatostatin receptor 2 (SST2)Filamin A (FLNA) phosphorylationcAMP/PKA pathwayCell cytoskeletonSignal transductionAn efficient intracellular response to somatostatin analogs (SSA) in pituitary tumors requires filamin A (FLNA). Since cAMP pathway plays an important role in GH-secreting pituitary tumors ...
First, we confirmed that somatostatin receptor 2 (SSTR2) is an ideal cancer cell surface target by analyzing 38 patient-derived NET tissues, 33 normal organs, and three NET cell lines. Then, we developed a new monoclonal antibody (mAb, IgG1, and kappa) to target two extracellular domains ...