and contain lipids, proteins, mRNAs, and miRNAs [18,19]. Additionally, because exosomes are fused to the cell membrane of peripheral or distant cells and serve to deliver various biomolecules, they are recognized as important transmitters in intercellular ...
In vertebrates, four paralogues have been identified (SALL1-4), and SALL2 is the family’s most dissimilar member. SALL2 is required during brain and eye development. It is downregulated in cancer and acts as a tumor suppressor, promoting cell cycle arrest and cell death. Despite its ...
Recent reports indicate that a subgroup of tumor cells named cancer stem cells (CSCs) or tumor initiating cells (TICs) are responsible for tumor initiation, growth and drug resistance. This subgroup of tumor cells has self-renewal capacity and could differentiate into heterogeneous tumor cell populat...
影响因子(2023) 1.321Tumor Biology is a peer reviewed, international journal providing an open access forum for experimental and clinical cancer research. Tumor Biology covers all aspects of tumor markers, molecular biomarkers, tumor targeting, and mechanisms of tumor development and progression. Specific...
The pathophysiological roles and the therapeutic potentials of Myc family are reviewed in this article. The physiological functions and molecular machineries in stem cells, including embryonic stem (ES) cells and induced pluripotent stem (iPS) cells, are
cells, which is similar to inhibitory effects of miR-152. Moreover, exogenous expression of KIT compromises inhibitory effects of miR-152 on cell proliferation and colony formation. Our findings suggest that mir-152 inhibits cell proliferation and colony formation of CD133+hep3B cells by targeting...
Stem Cells and Prostate Cancer || is the existence of a stem cell with tumorigenic properties capable of regenerating all the differentiated cell types presented in the original tumor. The... Cramer,D Scott - Springer New York 被引量: 14发表: 2013年 Ovarian Stem Cell Biology and the Emergenc...
Additional to autophagy inhibition, verteporfin reduces [131,133] transcriptional co-activators that regulate the Hippo pathway, implicated in cell growth and stem cell function [180]. Verteporfin inhibits cell proliferation, angiogenesis, and migration, and induces apoptosis [181]. It inhibits autophagy...
Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology. Cold Spring Harb. Symp. Quant. Biol. 73, 513-522. doi: 10.1101/sqb.2008.73.048Krizhanovsky V, Xue W, Zender L, Yon M, Hernando E & Lowe SW (2009) Implications of cellular ...
FFPE sections were then stained for multiple additional markers and analyzed by fluorescence microscopy. (b) GL261 tumor cells were inoculated on day 0. Before the start of therapy, two weeks after tumor cell inoculation, first MRI was conducted to verify tumor growth. On day 21, a second ...