TB was recognized as a clinical entity as far back as 1000 BC. However, it was not until 1744 that Morgagni,1 following a postmortem examination of a 20-year-old woman who died of TB and whose uterus and fallopian tubes were found to be filled with caseous material, described the first...
An in vitro blood test based on interferon-gamma release assay (IGRA) with antigens specific for M tuberculosis can also be used to screen for latent TB infection. Patients suspected of having TB should submit sputum for acid-fast bacilli (AFB) smear and culture. (See Workup.) The usual ...
TB = mycobacterium tuberculosis; SOT = solid organ transplant; TST = Tuberculin skin test; CXR = Chest radiograph; IGRA = interferon gamma release assay; LTBI: Latent TB infection; % agreement includes agree and strongly agree answers to questionnaire. Comparison by Fisher'...
Combating the spread of drug resistant tuberculosis is a global health priority. Whole genome association studies are being applied to identify genetic determinants of resistance to anti-tuberculosis drugs. Protein structure and interaction modelling are
The only approved TB vaccine currently BCG (Bacillus Calmette-Guérin) which is injected intradermally has challenges because of variables in genetic variance among demographics, genetic heterogeneity in BCG strains, the impact of non-tuberculous mycobacteria (NTM), and that of some parasite illnesses ...
There is urgent need for new drug regimens that more rapidly cure tuberculosis (TB). Existing TB drugs and regimens vary in treatment-shortening activity, but the molecular basis of these differences is unclear, and no existing assay directly quantifies
In this article, we give an overview of new technologies for the diagnosis of tuberculosis (TB) and drug resistance, consider their advantages over existing methodologies, broad issues of cost, cost-effectiveness and programmatic implementation, and their clinical as well as public health impact, foc...
To address increasing tuberculosis (TB) incidence in foreign-born populations, immigrant TB screening programs have been implemented in the USA. These programs are modified periodically, the effectiveness of which have been disputed. The aim of this retr
et al. EUSeqMyTB to set standards and build capacity for whole genome sequencing for tuberculosis in the EU. Lancet Infect. Dis. 18, 377 (2018). Announcement of the European Centre for Disease Prevention and Control efforts to establish and validate the use of WGS for all TB public health...
Tuberculosis (TB), caused by members of theMycobacterium tuberculosiscomplex (MTBC), is among the ancient scourges of humankind1, and remains the leading cause of mortality globally due to an infectious disease2. Intense research has been dedicated to decipher the evolutionary history of the MTBC ...