Viral coinfection significantly suppresses Mtb-specific IFN-纬 production, with elevated bacterial loads and hyperinflammation in the lungs. Type I IFN signaling blockade rescues the Mtb-specific IFN-纬 response and ameliorates lung immunopathology. Single-cell sequencing, tissue immunofluorescence staining,...
(atrophy, cachexia) and myopathies, such as Danone disease, bacterial and viral infections, including military tuberculosis, group A streptococcus, virus of... CH BRAKHMANN,US FINAN PITER,FR FRICH KRISTINE,... 被引量: 0发表: 2013年 Supplemental Studies on the Electrolytes Variation in Serum ...
(Fig. 5b). Thus, TNF signalling in human GM-CSF-matured MDMs is crucial for the control of L. monocytogenes infection and/or replication. Finally, we infected AML cells generated from healthy controls and TNF-deficient patients with live M. tuberculosis in the presence or absence of TNF (...
In vivo mouse infection studies demonstrated a significant decrease in lung bacterial load and pathology when infected animals were treated with metformin [52]. However, when used as an adjunct therapy with first-line antibiotics, no significant changes were observed [53], indicating that addition ...
Viral Load and Risk of Tuberculosis in HIV Infection. J Acquir Immune Defic Syndr, Volume 71, Number 2, February 1, 2016 The evaluation of delayed-type hypersensitivity immune responses by the tuberculin skin test and, more recently, by ex vivo IFN-纬 release assays (IGRAs) f... C Lange...
The first strategy uses subunit vaccines in the form of protein–adjuvant formulations, naked DNA, or recombinant bacterial or viral carriers that express defined antigens. Promising results have been obtained, but so far no vaccine candidate tested in animal models has proven to be better than ...
The most common infections in this single-center study were bacterial followed by viral and fungal. Mycobacterial infections were the most common opportunistic infection, and a significant number were extrapulmonary. Higher disease activity at baseline, presence of gastrointestinal disease, lower baseline ...
Some studies documented that these variants have been associated with bacterial and viral infection [79], [81]. Previous study suggests that DC-SIGN −336A/G and −871A/G had significant associations with tuberculosis infection [82]. Recently, a study investigating the associations between DC...
“adaptive”: they can incorporate fragments of invasive sequences as new spacers. This adaptation is mediated by two specific Cas proteins shared by all CRISPR-Cas systems, the Cas1 and Cas2. This mechanism ensures bacterial adaptation to the effective viral populations they are exposed to [14...
More recently, a non-canonical inflammasome has been described in Gram-negative bacterial infection that activates caspase-11 in mice (orthologue of caspase-4/5 in humans) through a lipopolysaccharide-dependent pathway46,47. Although MTB does not contain lipopolysaccharide, the bacilli have lipid- ...