Infectious Disease | One of two purified-protein derivative tuberculin products licensed by the FDA will be unavailable until the end of May, according to a recent Morbidity and Mortality Weekly Report. Sanofi-Pasteur Limited, manufacturer of...
Manufacturer of Tubersol states that the tuberculin skin test should not be administered to persons with documented active tuberculosis or a clear history of treatment of TB infection or disease, and to persons with extensive burns or eczema.Warnings...
Sign up with one click: Facebook Twitter Google Share on Facebook tuberculin (redirected fromTuberculin Units) Thesaurus Medical Encyclopedia tu·ber·cu·lin (to͝o-bûr′kyə-lĭn, tyo͝o-) n. A sterile liquid containing proteins extracted from cultures of tubercle bacilli and used in...
However, since a single batch of PPDs from a reputable manufacturer was used to test all animals in our study, this is unlikely to play a major role in the observed differences in test results with the DST. Another source of variation long recognized is exposure to environmental mycobacteria ...
A bovine tuberculin is considered acceptable for diagnosis in the eradication programmes if it has a minimum potency of 2,000 IU per dose and if the estimated potency is between the 66% and the 150% of the potency stated by the manufacturer on the label. Potency estimations in guinea pigs ...
HIV-1 infection results in the depletion of Mtb specific CD4 cells [2] and impaired effector responses to Mtb antigens, which could result in a false negative test for latent TB. For TST, where diameter of skin induration is measured, a lower cut-off of 5 mm rather than 10 mm is ...
Interferon-gamma release assays have emerged as a more specific alternative to the tuberculin skin test (TST) for detection of tuberculosis (TB) infection, especially in Bacille Calmette-Guérin (BCG) vaccinated people. We determined the prevalence of Mycobacterium tuberculosis infection by TST and Qua...
The corrected mean IFN-γ level of 0.08 IU/ml and corresponding empirical threshold (0.05) of false-positive QIAreach results were significantly lower than the manufacturer-recommended QFT-Plus threshold (≥ 0.35 IU/ml). Despite QIAreach's higher sensitivity at equivalent specificity to TST, the ...
The manufacturer defined assay cut-off points are: >0.35 IU/ml for QFT-GIT; and spots for T-SPOT The within-subject short-term variability for the QFT test is +/-80% of IFN-gamma response and for T-SPOT it is +/-3 spots. The borderline or uncertainty zone for the QFT is 0.2-...