In silico analysis of TTR gene (coding and non-coding regions, and interactive network) and its implications in transthyretin-related amyloidosis. Amyloid. 2014;21(3):154-62.Polimanti, R. , G. M. Di , D. Manfellotto , and M. Fuciarelli . 2014 . In silico analysis of TTR gene (...
Analysis of Mitochondrial Haplogroups Associated With TTR Val30Ala Familial Amyloidotic Polyneuropathy in Chinese Patientsfamilial amyloidotic polyneuropathymitochondrial haplogrouptransthyretin (TTR) geneExtracellular deposition of abnormal transthyretin (TTR) amyloid fibrils leads to familial amyloidotic polyneuropathy...
Protein analysis of this TTR variant revealed the substitution of arginine for proline at position 102 of the TTR polypeptide chain. This result was confirmed by DNA analysis of PCR amplified DNA.关键词:Transthyretin Basic variant Amyloidosis Polymorphism Peptide mapping Plasma protein ...
Identification of a new hereditary amyloidosis prealbumin variant, Tyr-77, and detection of the gene by DNA analysis. In the last several years, five human plasma prealbumin (transthyretin) variants have been discovered in association with hereditary amyloidosis, a late-on... MR Wallace,FE Dwulet...
例如,如中国仓鼠卵巢(CHO)细胞的哺乳动物细胞,与诸如来自人巨细胞病毒的主要中间早期基因启动子元件的载体缀合,是抗体的有效表达系统;见,例如,Foecking等人,Gene45(1986),101;Cockett等人,Bio/Technology8(1990),2。用于蛋白表达的宿主细胞系通常是哺乳动物来源的;本领域的技术人源被认为具有能力优先确定哪些是最...
This report reflects the analysis of an extracted genomic DNA sample. In very rare cases, (circulating hematolymphoid neoplasm, bone marrow transplant, recent blood transfusion) the analyzed DNA may not represent the patient's constitutional genome.Show more Order gene TTR - Diagnostic Add to order...
5 Reilly MM, Adams D, Booth DR et al: Transthyretin gene analysis in European patients with suspected familial amyloid polyneuropathy. Brain 1995; 118 (Part 4): 849–856. 6 Ando Y, Nakamura M, Araki S: Transthyretin-related familial amyloidotic polyneuro- pathy. Arch Neurol 2005; 62: 1057...
Eplontersen: 一种TTR抑制剂药物,由Ionis Pharmaceuticals, Inc. (Ionis Pharmaceuticals, Inc.)公司最早进行研发,目前全球最高研发状态为批准上市,作用机制: TTR抑制剂(转甲状腺素蛋白抑制剂),治疗领域: 神经系统疾病,遗传病与畸形,内分泌与代谢疾病,其他疾病,心血管疾
(AL-CA). It highlights therapies for ATTR-CA that focus on interrupting the process of amyloid fibril formation. These therapies include transthyretin stabilizers, gene silencers, and monoclonal antibodies, which have shown the potential to improve patient outcomes and survival rates significantly. As ...
gene expression study of human hepatic stellate cells in HBV related-hepatocellular carcinoma[J]. Journal of Experimental & Clinical Cancer Research Cr,2012,32 5 (12):1-10. [12] Barrow H,Rhodes JM,Yu LG. Simultaneous determination of serum galectin-3 and-4 ...