在TTR相关疾病的研究中，研究最多的是TTR相关淀粉样变性病，如转甲状腺素蛋白淀粉样变性心肌病（Transthyretin Cardiac Amyloidosis Myocardiopathy，ATTR-CM） [15]、转甲状腺素蛋白淀粉样变性多发性神经病（Transthyretin Amyloid Polyneuropathy，ATTR-PN） [16]，以及阿尔兹海默症（Alzheimer's Disease，AD） [17]。TTR...
在TTR相关疾病的研究中,研究最多的是TTR相关淀粉样变性病,如转甲状腺素蛋白淀粉样变性心肌病(Transthyretin Cardiac Amyloidosis Myocardiopathy,ATTR-CM) [15]、转甲状腺素蛋白淀粉样变性多发性神经病(Transthyretin Amyloid Polyneuropathy,ATTR-PN) [16],以及阿尔兹海默症(Alzheimer's Disease,AD) [17]。TTR还与多种...
Cardiac amyloidosis is a condition where protein builds up in the heart. This buildup can lead to heart failure. A protein called transthyretin accounts for more than 23% of cardiac amyloidosis cases in people with African ancestry. Mutations in the gene that codes forHI Works...
19.Giblin GT, Cuddy SAM, González-López E, et al. Effect of tafamidis on global longitudinal strain and myocardial work in transthyretin cardiac amyloidosis [J]. Eur Heart J Cardiovasc Imaging, 2022, 23 (8): 1029-1039. 20.Shah SJ, Fine N, Garcia-Pavia P, et al. Effect of tafamidis...
*Also known as ATTR cardiomyopathy, or ATTR cardiac amyloidosis (ATTR-CA). Learn More This site is intended for US Healthcare Professionals only. TTR, also known as prealbumin, plays a role in processes vital to human health:4,5 Highly conserved transport protein produced in the liver ...
L. Transthyretin (TTR) cardiac amyloidosis. Circulation 126, 1286–1300 (2012). 15. Bergstrom, J., Engstrom, U., Yamashita, T., Ando, Y. & Westermark, P. Surface exposed epitopes and structural heterogeneity of in vivo formed transthyretin amyloid fibrils. Biochem. Biophys. Res. Commun. ...
The most common amyloidogenic TTR variant -- Val122Ile, which is associated predominantly with a cardiac phenotype and has a late onset -- is present in 3% to 4% of African Americans. "However, I think more important, broadly, is suspicion -- clinical suspicion," he said. "I think many...
Cardiac amyloidosis: a review and report of a new transthyretin (prealbumin) variant. Like polyneuropathy, cardiac amyloidosis is a prominent clinical feature of hereditary amyloidosis, namely of the autosomal dominant transthyretin (TTR) type. ... A Hesse,K Altland,RP Linke,... - 《British Heart...
1235;斯坦欧(stangou)等人,继发于家族性淀粉状蛋白多发性神经病肝移植后的进行性心脏淀粉样变性:对淀粉样蛋白原纤维形成的影响(progressive cardiac amyloidosis following liver transplantation for familial amyloid polyneuropathy:implications for amyloid fibrillogenesis),移植(transplantation),1998,66:229 ...
This multi-center effort represents the largest collection of AL and TTR cardiac amyloidosis to date. We present data on 79 patients from 3 centers. For AL amyloid patients, OHT+SCT and for TTR amyloid, either OHT alone or OHT+OLT offer improv...