Atypical HUS; Hemolytic uremic syndrome; HUS; Thrombotic microangiopathy; Thrombotic thrombocytopenic purpura; TMA; TTP Definition Discussing kidney involvement in thrombocytopenic purpura (TTP)/hemolytic uremic syndrome (HUS) is complicated because exactly what disease is identified by these diagnoses has b...
Only 1 patient with iTTP had a medical history of gastric cancer, which was treated with chemotherapy. Plasma ADAMTS13 activity was below 3% in all cases, and the median value of functional antibody was 2.5 BU/mL (range, 0.5-113 BU/mL). Both severe thrombocytopenia (median platelet count,...
Given that TTP is considered a medical emergency, waiting for ADAMTS13 activity results is not recommended, as therapeutic plasma exchange may be life-saving in a patient with high suspicion of TTP [20]. Major advances in TTP understanding have occurred over the last fifteen years. Several ...