Full size image In addition, the expression of miR-320a was downregulated by TTN-AS1 overexpression and upregulated by TTN-AS1 knockdown, and these effects could be abolished by miR-320a mimics and antagomiR-320a, respectively (Supplementary Fig. S6A, B). However, no significant difference ...
The titin locus located on chromosome 2q24 in the human genome expresses about 100kb full-length mRNAs, that are translated into giant up to 34.350-residue large polypeptides. Therefore, titin is by far the largest known protein. The titin protein is abundant in vertebrate muscles, where it ...