Thus,-positive tumors may form a distinct entity among lung adenocarcinomas, characterized by young onset, acinar histology, no or rare mutations in,, and, and a TTF-1 cell lineage, all in agreement with the pr
innon-smallcelllungcancer(NSCLC)andtoevaluatetheirclinicalsigni cance.Methodseexpressiono TF-1andp63 rom404NSCLCand28benignpulmonarydisease(BPD)tissuespecimensweredetectedbyimmunohistochemicalEnVision two-stepmethod,togetherwiththeirclinicopathologicdata.Resultsepositiverateo TF-1andp63proteininNSCLCtis- ...
Lung cancer Histology Adenocarcinoma Lung cancer is the leading cause of cancer death worldwide,1 and the incidence of adenocarcinoma of the lung is increasing.2 It is well known that pulmonary adenocarcinomas show a wide variety of histologic features such as papillary, acinar (tubular), solid, ...
Differential diagnosis between malignant lymphoma and metastatic duodenal cancer was endoscopically difficult. The histology of biopsied specimens was poorly differentiated adenocarcinoma. Immunohistochemical analysis revealed a positive reaction for thyroid transcription factor-1 (TTF-1). Thus, we concluded that...
The histology of biopsied specimens was poorly differentiated adenocarcinoma. Immunohistochemical analysis revealed a positive reaction for thyroid transcription factor-1 (TTF-1). Thus, we concluded that these were metastatic duodenal tumors from lung adenocarcinoma. Two courses of gemcitabine led to a ...
The aim of this study was to assess the utility of immunohistochemical markers performed on small biopsies to predict the final histology in excision specimens. De facto small biopsies were made by creating a TMA from consecutive cases of resected lung cancer. Immunohisto-chemistry was performed on...
The histology of biopsied specimens was poorly differentiated adenocarcinoma. Immunohistochemical analysis revealed a positive reaction for thyroid transcription factor-1 (TTF-1). Thus, we concluded that these were metastatic duodenal tumors from lung adenocarcinoma. Two courses of gemcitabine led to a ...
Thus,EML4-ALK-positive tumors may form a distinct entity among lung adenocarcinomas, characterized by young onset, acinar histology, no or rare mutations inEGFR,KRAS, andTP53, and a TTF-1 cell lineage, all in agreement with the prevalence in non- or light smokers....
Small cell lung cancerHistologyThyroid transcription factorPrognosisBackground The aim of this study was to analyze the frequency of Thyroid Transcription Factor (TTF)-1 expression in small cell lung cancer (SCLC) and its value for the diagnosis of SCLC, the response to first line treatment as ...