患者在Eclipse 11计划系统(treatment planning system,TPS)上做逆向调强放疗计划,采用6～8野照射技术,计划靶区分为胸壁(乳腺)照射区±锁骨上淋巴引流照射区。 1.3 甲状腺转录因子血液标本的留取及检测 本研究中检测血液标本甲状腺...
We present the case of a 57-year-old female with recurrent BRAF V600E-mutated TTF-1-positive PPT treated with a BRAF inhibitor monotherapy (dabrafenib) leading to tumor regression. After 18months of uninterrupted treatment, ongoing radiological tumor regression was observed and the patient remained...
(P<0.05). The positive rates of TTF -1 and Napsin A had no significant difference with age and gender (P >0.05),and had significant differ-ence with tumor size,differentiation degree and TNM stage (P <0.05). The sensitivity and specificity of combination detection of TTF -1 andNapsin A...
Among patients with lung ade- nocarcinoma, those with TTF-1-positive cancer exhibit better prognosis than those with TTF1-negative cancer [4-6]. Using a transgenic lung cancer mouse model, deletion of TTF-1 has been shown to promote invasion and me- tastasis of lung adenocarcinoma, in ...
positive.When calculating the protein expression positive rate weak positive as well as positive was defined as positive group. All data were analyzed by SAS9.0 software.The expression difference of CK7、CK5、T订-1,and the expression rates ofCK7、CK5、T]陌一1 were analyzed with the clinical ...
To validate the association of BRN2 with TTF1 expression, we established BRN2-inducible TKB1 and A549 cells using the same methodology. Recombinant TTF1 iso- form 1 and 2 proteins used as positive controls in the western blot analysis were prepared through the transient transfection of pTTF1 ...
EGFR mutation in exon 21 positive patients showed the survival was obviously better (P<0.001).Conclusion TTF-1 can be used as an independent predictor to predict prognosis in NSCLC.Further, EGFR mutations can better predict the prognosis of NSCLC patients and guide clinical diagnosis and treatment...
levels of Ki-67 and TTF-1 and the quantitative parameters of dual-energy CT. Chi-square t e s t was used to analyze the differences of general clinical characteristics and dual-energy C T quantitative parameters between Ki-67 high and low value group and TTF-1 negative and positive groups...
EGFR mutations were significantly more common in tumors with thyroid transcription factor-1 (TTF-1) expression than those without TTF-1 (p < 0.001), and almost all (92.7%) mutated adenocarcinomas were TTF-1 positive. Conclusions: The incidence of EGFR mutations is variable according to ...
The plot discloses a clear inverse linear dependence between TTF1 and p40: as one shows a certain level of positive activity, the other prevalently shows the same level of negative activity. This provided further evidence that the two TFs were Figure 1. Gene co-expression network of...