Castiglioni et al., "Thrombospondin (TSP) and transforming growth factor beta 1 (TGF-尾) pro- mote human A549 lung carcinoma cell plasminogen activator inhibitor type 1 (PAI-1) production and stimulate tumor cell attachment in vitro," Biochemical and Biophysical Research Communications, vol. 203,...
1、Product Data SheetLSKL, Inhibitor of Thrombospondin (TSP-1)Cat. No.: HY-P0299CAS No.: 283609-79-0分式: CHNO分量: 458.6Sequence: Leu-Ser-Lys-LeuSequence Shortening: LSKL作靶点: TGF- Receptor作通路: TGF-beta/Smad储存式: Powder -80C 2 years-20C 1 yearIn solvent -80C 6 months-20C ...
Since TSP-1 activates TGF-beta1, we investigated whether RA stimulates the activation of TGF-beta1 through up-regulation of TSP-1 in RPE cells. METHODS: Human RPE cells were cultured with RA or TSP-1. The active form of TGF-beta1 in the culture medium was measured by enzyme-linked ...
TGF-β Receptor r i e 作⽤通路: TGF-beta/Smad s 储存⽅式: Powder -80°C 2 years -20°C 1 year In solvent -80°C 6 months -20°C 1 month 溶解性数据 体外实验 DMSO : ≥ 100 mg/mL (218.05 mM) H O : 50 mg/mL (109.03 mM; Need ultrasonic) 2 * ≥ means soluble, but ...
臻替米沙坦对糖尿病大鼠肾脏中TSP.1/TGF—p1/Smad通路的影响研究生沈育芬导师张会娟郑州大学第一附属医院内分泌科郑州450052摘要背景与目的.近来研究发现,转化生长因子一pl(transforminggrowthfactor—betal,TGF-p1)在糖尿病肾病(DiabeticNephropathy,DN)的发生发展中起着重要的作用。然而,通过转录和翻译后释放出来的TGF....
LSKL, Inhibitor of Thrombospondin (TSP-1) 通过抑制 TSP-1 介导的 TGF-β1 活性来抑制蛛网膜下纤维化,防止慢性脑积水的发生并改善蛛网膜下腔出血后的长期神经认知缺陷。LSKL, Inhibitor of Thrombospondin (TSP-1) 可以轻松穿越血脑屏障。 研究领域:TGF-beta/Smad 作用靶点:TGF-β Receptor In Vitro: The ...
The amounts of both total and active TGF-β1 were significantly reduced in TSP1-null and double-TSP1/TSP2-null wounds compared to those in wild-type and TSP2-null wounds (Figure 7), but the ratios of active to total TGF-β1 were similar in all four groups of animals (wild-type, ...
thus, TSP-1 and TGF-β signaling pathway were anchored (Fig.S1B). Furthermore, co-immunoprecipitation (Co-IP) and immunofluorescence were conducted to examine whether Sestrin2 could interact with TSP-1. The results showed that there was an interaction between Sestrin2 and TSP-1 (Fig.S1C, ...
LSKL, Inhibitor of Thrombospondin TSP-1,CAS:283609-79-0,LSKL,InhibitorofThrombospondin(TSP-1)是一种四肽,源于潜在联系多肽,能够抑制TSP-1的活性,来降低TGF-β的活性,能够阻止肝损伤和肝纤维化。
TSP-1 is an endogenous activator of transforming growth factor-beta (TGF-β), which is involved in developing many fibrosis diseases, including liver fibrosis, renal fibrosis and fibrosis complications of multiple myeloma15,16. Eliminating TSP-1 function in renal fibrosis induced by unilateral ...