5. Gans MD, Gavrilova T. Understanding the immunology of asthma: Pathophysiology, biomarkers, and treatments for asthma endotypes. Paediatr Respir Rev. 2020;36:118-127. 6. Israel E, Reddel H K. Severe and difficult-to-treat asthma in adults[J]. New England Journal of Medicine, 2017, 377...
Explore BPS Bioscience’s insights into targeting TSLP for treating asthma and COPD. Discover research tools and strategies for advancing therapeutic development.
AsthmaCombination therapyBackground Severe asthma is a complex and chronic respiratory disease, and current conventional treatments are not effective in controlling the patients' condition. Thymic stromal lymphopoietin (TSLP) is a key regulatory factor in the initiation and maintenance of asthma. Thus, ...
2024年3月1日,美国罗克维尔和中国苏州——信达生物制药集团(香港联交所股票代码:01801),一家致力于研发、生产和销售肿瘤、自身免疫、代谢及心血管、眼科等重大疾病领域创新药物的生物制药公司,宣布IBI3002的首次人体(FIH)临床I期研究已在澳大利亚完成首例受试者给药。IBI3002是一种全球首创(first-in-class)的靶向白...
application to the Centre for Drug Evaluation of the National Medical Products Administration (NMPA) inChinafor HBM9378/SKB378 for the treatment of COPD inNovember 2024. The company has also completed a phase I clinical trial ...
including atopic derma- titis18 and asthma.19 It has additionally been reported to promote antibody isotype class switching in B cells,20 to regulate the development of Foxp3 þ Tregs in the human thymus,19,21 and to promote basophil hematopoiesis.22 1Swiss Vaccine Research Institute and Global...
It could then be considered as an interesting potential target for therapies in severe asthma [25] as it has been related to the severity of airway obstruction [26]. IL-23 appeared also increased in bronchial biopsies of COPD patients compared to healthy controls [27]. Induced sputum (IS) ...
Besides bronchial thermoplasty, which is only applied to patients with severe asthma, no other therapeutic strategy reduces airway wall remodeling. The major problem for tackling airway wall remodeling in asthma is the fact that the term summarizes a large variety of structural changes in the airway...
5. Gans MD, Gavrilova T. Understanding the immunology of asthma: Pathophysiology, biomarkers, and treatments for asthma endotypes. Paediatr Respir Rev. 2020;36:118-127. 6. Israel E, Reddel H K. Severe and difficult-to-treat asthma in adults[J]. New England Journal of Medicine, 2017, 377...
The present invention provides antibody treatments for asthma, including severe asthma, eosinophilic asthma and non-/hypoeosinophilic asthma. [0010] The present disclosure provides a method of treating asthma in a subject comprising administering a therapeutically effective amount of an anti-TSLP antibody...