甲状腺素通过负反馈回路(a negative feedback loop)抑制促甲状腺激素(TSH)的释放。首先,垂体特异性II型5’脱碘(DIO2)酶将甲状腺素(T4)转化为其活性代谢物三碘甲状腺原氨酸(T3)。T3然后与甲状腺激素核受体β (THRB)结合,THRB在促甲状腺素细胞中强烈表达。最后,THRB下游的...
甲状腺素通过负反馈回路(a negative feedback loop)抑制促甲状腺激素(tsh)的释放.首先,垂体特异性ii型5'脱碘(dio2)酶将甲状腺素(t4)转化为其活性代谢物三碘甲状腺原氨酸(t3).t3然后与甲状腺激素核受体β (thrb)结合,thrb在促甲状腺素细胞中强烈表达.最后,thrb下游的细胞内信号在转录和翻译后水平上抑制trh和tsh...
TSH stimulates positively the production of thyroid hormones T4 and T3. Circulating T4 and T3 regulate the TSH secretion by negative feedback. TSH production is also under the positive control of thyrotropin-releasing hormone (TRH), which is secreted by hypothalamus. ...
TSH stimulates positively the production of thyroid hormones T4 and T3. Circulating T4 and T3 regulate the TSH secretion by negative feedback. TSH production is also under the positive control of thyrotropin-releasing hormone (TRH), which is secreted by hypothalamus. ...
Thyroid hormones (T3 and T4) synthesized by thyroid gland and play an essential role in normal body development and tissue metabolism. Iodine is an essential factor that is required for the synthesis of thyroid hormones. The secretion of thyroid hormones is regulated by Negative feedback mechanism...
甲状腺素通过负反馈回路(a negative feedback loop)抑制促甲状腺激素(TSH)的释放。首先,垂体特异性II型5’脱碘(DIO2)酶将甲状腺素(T4)转化为其活性代谢物三碘甲状腺原氨酸(T3)。T3然后与甲状腺激素核受体β (THRB)结合,THRB在促甲状腺素细胞中强烈表达。最后,THRB下游的细胞内信号在转录和翻译后水平上抑制TRH和TS...
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TSH concentrations are measured as part of a first-line thyroid function test in patients suspected of having hyperthyroidism or hypothyroidism of thyroid hormones. Interpretation of the results depends on both the TSH and T4 concentrations. In some situations measurement of T3 may also be useful. ...
Thyroid hormones act on a feedback loop. The pituitary gland is signaled to stop producing thyroid stimulating hormone when there is an adequate amount of the thyroid hormones, thyroxine (T4), and triiodothyronine (T3), in the blood. When something other than the pituitary gland causes excess ...
Somatostatin is also produced by the hypothalamus, and has an opposite effect on the pituitary production of TSH, decreasing or inhibiting its release.The level of Thyroid hormones (T3 and T4) in the blood have an additional effect on the pituitary release of TSH, When the levels of T3 and...