Yang T, Zhu L, Zhai Y, Zhao Q, Peng J, Zhang H, Yang Z, Zhang L, Ding W, Zhao Y: Tsc1 controls il-1beta expression in macrophages via mtorc1-dependent c/ebpbeta pathway. Cell Mol Immunol 2016;13:640-650.Yang T, Zhu L, Zhai Y, Zhao Q, Peng J, Zhang H,...
In post-mitotic neurons, Tsc1/2-mTORC1 signaling controls neuronal communication in a cell type-specific manner via regulation of membrane excitability, synaptic transmission, and synaptic plasticity6,7,8,9,10,11,12,13,14,15. Loss-of-function mutations in negative regulators of mTORC1 cause neu...
此外,在机制水平,利用NSE特异条件性基因敲除TSC1小鼠模型,我们的研究结果表明,持续激活mTORC1可以打破耳蜗内的氧化还原平衡,从而导致早发的耳蜗毛细胞死亡和渐进性听力损失.在本论文中,我们使用两个有效的动物模型第一次阐明了 mTORC1通路在ARHL中的关键作用.这些结果表明,靶向mTORC1通路可能对预防和治疗ARHL提供新的...
The siRNA knockdown and gene KO studies showed that DEPTOR and the HIF1-REDD1-TSC1 axis are responsible for MLN4924-induced autophagy via inhibiting mTORC1. Biologically, autophagy is a survival signal to tumor cells, and blockage of autophagy via siRNA knockdown, gene KO and small molecule ...
作者们观察到,强激活pkg1通路的药物西地那非也阻断了由压力超负荷引起的心脏肥大的发展。RANEK等接着确定了一种以前未知的机制,pkg1抑制mtorc1信号。 蛋白质tsc2是所有组织中mtorc1活性的关键调节因子。tsc2与另一种蛋白质tsc1形成复合物,以抑制蛋白质rheb,mtorc1的直接激活物。生长促进信号抑制tsc2,从而阻止其...
Tsc1 deletionScope To test whether myeloid cells Tsc1 deletion and therefore constitutive activation of the nutrient sensor mTORC1 protects from high‐fat diet (HFD)﹊nduced obesity, glucose intolerance and adipose tissue inflammation. Methods and Results Mice with Tsc1 deletion in myeloid cells (...
ummary The tuberous sclerosis complex (TSC) tumor suppressors form the TSC1-TSC2 complex, which limits cell growth in response to poor growth conditions. Through its GTPase-activating protein (GAP) activity toward Rheb, this complex inhibits the mechanistic target of rapamycin (mTOR) complex 1 (...
The tuberous sclerosis complex (TSC) tumor suppressors form the TSC1-TSC2 complex, which limits cell growth in response to poor growth conditions. Through its GTPase-activating protein (GAP) activity toward Rheb, this complex inhibits the mechanistic target of rapamycin (mTOR) complex 1 (mTORC1)...
In tuberous sclerosis (TSC), elevation of mammalian target of rapamycin complex 1 (mTORC1) activity has been proposed to compound the induction of UPR transcription factors ATF4 and CHOP, suggesting that the UPR could be targeted to eradicate TSC1/2-null cells during patient therapy. Here we ...
实验发现,无论在ISCs细胞中还是在Villin-Cre;Tsc1f/f小鼠模型中,mTORC1蛋白在老龄小鼠肠绒毛老化过程中发挥着关键作用,而这种老化过程并非不可逆。 ✅确定mTORC1调控肠绒毛老化中的关键信号通路 研究人员通过一系列的研究,逐步明确了mTROC1-MKK6-p38MAPK-p53通路在肠绒毛老化中发挥着关键作用,并为逆转肠绒毛老化...