All the GAP domains provide positively charged residues, neutralize negative charges generated during phosphoryl transfer reactions, and thus accelerate GTP hydrolysis25,26. Ras–RasGAP represents the prototypic small GTPase–GAP system, in which a trans-arginine finger (R789 in RasGAP) and a cis-...
All unique reagents generated in this study are available from the Lead Contact with a complete Material Transfer Agreement. Data and Code Availability All software used in this study are listed in the Key Resources Table. The cilia genes expression data and the primary screen data generated in ...
PLX5622 was obtained under a material transfer agreement with Plexxikon. All data needed to evaluate the conclusions in the paper are present in the paper. Acknowledgments We thank Evangelina Lugo and Kyra Dingle for their excellent contributions to the development, maintenance and treatment of the ...
Mutations to the TSC1 and TSC2 genes cause the disease tuberous sclerosis complex. The TSC1 and TSC2 gene products form a protein complex that integrates multiple metabolic signals to regulate the activity of the target of rapamycin (TOR) complex 1 (TORC
Netperf根据应用的不同,可以进行不同模式的网络性能测试,即批量数据传输(bulk data transfer)模式和请求/应答(request/reponse)模式。Netperf 工具以 client/server 方式工作。server 端是 netserver,用来侦听来自 client 端的连接,client 端是 netperf ,用来向 server 发起网络测试。
Bar Code Validation 18 ~ DE - Download Encoding Table 18 ^DF - Download Format 18 ~DT - Download Bounded TrueType Font18 ~DU - Download Unbounded TrueType Font 19 ~EF / ^EF - Erase Format 19 ~EG / ^EG - Erase Downloaded Images 19 ^FA - Field Allocate 19 ^FC - Field Clock 19 ...
After transfer to a nitrocellulose membrane the proteins were detected with rabbit anti-Tmem59 antibodies at 1:1000 dilution (ThermoFisher Catalog #PA5-21575, Abcam Catalog #ab97597, or ProteinTech Catalog #24134-1-AP) using a BioRad ChemiDoc touch imaging system. Nephron counts HCl maceration...
eEF2 is a GTP-dependent elongation factor that promotes transfer of peptidyl-tRNAs from the A to P site of the ribosome. Phosphorylation of eEF2 on threonine 56 prevents it from binding to ribosomes, leading to inhibition of translation elongation [61]. Somewhat counterintuitively, eEF2 kinase...
To “convey” a work means any kind of propagation that enables other parties to make or receive copies. Mere interaction with a user through a computer network, with no transfer of a copy, is not conveying. An interactive user interface displays “Appropriate Legal Notices” to the extent th...
Act as a Technology Transferer Contributed by: @niyuzheno1 I want you to act as a Technology Transferer, I will provide resume bullet points and you will map each bullet point from one technology to a different technology. I want you to only reply with the mapped bullet points in the ...