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Data are mean ± s.d., n = 18 biologically independent samples, two-tailed unpaired Student’s t-test. b, From same experiment, PKG1 activation is found to be independent of the form of TSC2 expressed; n = 6 biologically independent samples, box and whisker and raw data plots. Data ...
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Statistical analysis: Student's t-test, *Pr0.05; **Pr0.01; ***Pr0.001. comparison to control shRNA-injected littermates (Fig. 2g). In line with the negative regulatory impact of TSC22D4 on hepatic insulin signalling (Fig. 1d), liver-specific overexpression of TSC22D4 significantly ...
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Use the MyTSC app and my.tsc.fl.edu portal for quick access to Canvas, Workday Student, email, calendars, communication with your TSC campus community and more. Our mobile application puts the people most critical to a quality college experience at your fingertips. ...
Although mammalian target of rapamycin 1 (mTORC1) negatively regulates autophagy in cultured cells, how autophagy impacts mTORC1 signalling, in particular in an in vivo setting, is less clear. Here we show that autophagy supports mTORC1 hyperactivation i