Tryptophan and depression: can diet alone be the answer? Objective: To compare the scientific content of recent general media articles on tryptophan, diet and depression, with recent empirical research into dietary manipulation of tryptophan published in the scientific literature. Method: A review of ...
Tryptophan also increases melatonin levels in your blood by up to four times the normal amount, and melatonin supplements are also popular sleep aids. Tryptophan is prescribed as an antidepressant, and is particularly effective in relieving manic depression and d...
RESULTS: TD was significantly related to increased scores on clinician-rated depression and anxiety scales, and on self-rated depression, anxiety, and somatic symptoms. The control challenge had no effect, despite the fact that the reductions in plasma tryptophan during the control session were unexp...
In this chapter, shifting tryptophan metabolism from serotonin synthesis to the generation of neuroactive metabolites, such as quinolinic acid and kynurenic acid, by the kynurenine pathway is now considered to play an important a role in the pathogenesis of inflammation-dependent depression. The ...
TRYPTOPHAN IN DEPRESSION L-tryptophan, the amino acid precursor of serotonin, was administered to 16 depressive patients in a double-blind study of its potential antidepressant eff... M Peet,RN Herrington - 《Lancet》 被引量: 5发表: 1974年 Studies of alpha-methyl-para-tyrosine, L-dopa, and...
Objective: To review the literature regarding the effectiveness of 5-hydroxytryptophan (5-HT) and L-tryptophan in the treatment of unipolar depression. Methods: A systematic review of the literature from 1966 to 2000 using the search terms 'tryptophan', 5-hydroxytryptophan', '5-HTP', '5-HT' ...
Serotonergic Function in Depression: Prolactin Response to Intravenous Tryptophan in Depressed Patients and Healthy Subjects There is considerable evidence that serotonergic function may be reduced in the brains of depressed patients. Serotonin is an effective stimulant of prolactin release, and intravenous ...
The antidepressive effect of tryptophan, with and without the addition of a monoamine-oxidase inhibitor, has been compared with electroconvulsive therapy (E.C.T.) in three groups of patients with severe depression. The results suggest that tryptophan was as effective as E.C.T. in treating depre...
cancer patients undergoing IFN-α and/or interleukin-2 therapy exhibited significant decreases in serum concentrations of tryptophan (TRP) and the ratio of TRP to large neutral amino acids (namely tyrosine, phenylalanine, leucine, isoleucine, valine) that correlated with increased depression scores (C...
Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice Manfei Zhou, Yichun Fan, Liuting Xu, Zheng Yu, Sizhe Wang, Huaisha Xu, Jiuping Zhang, Linwei ...