Tryptophan hydroxylase belongs to the AAA hydroxylase family and shares strong sequence identity with phenylalanine hydroxylase and tyrosine hydroxylase, and the enzyme is localized in neurons in the CNS and pe
The prognosis of advanced gastrointestinal stromal tumors (GISTs) was dramatically improved in the era of imatinib. (PFS) and BAPTA overall survival (OS) in individuals with advanced GISTs. Moreover from the timing of cytoreduction to imatinib we divided the medical individuals who had surgery treat...
The special nature of the synthesis of serotonin in the brain offers a unique way to alter serotonergic function in both animals and humans. The enzymetryptophan hydroxylase, which converts tryptophan to 5-hydroxytryptophan, is unsaturated at normal brain tryptophan concentrations; thus the synthesis ...
Tryptophan hydroxylase (TPH) is the rate-limiting biosynthetic enzyme for serotonin. Previously, we reported elevated levels of TPH protein in the dorsal raphe nucleus (DRN) of depressed suicides and now examine expression of neuronal TPH2 mRNA in a cohort of matched controls and depressed suicides...
Dietary TRP en- ters the body and is degraded through three main path- ways: the serotonin pathway via tryptophan hydroxylase 1 conversion, the tryptophan-indole pathway (which acti- vates aromatic hydrocarbon receptors and has four sub- pathways), and the KP pathway via the conversion of ...
Therefore, the corresponding levels of metabo- lites and scores were also compared between patients based on prescribed medication. The group of eight patients prescribed ACE inhibitors showed marginally lower levels of quinolinic acid and 3-OH anthranilic acid (all t-test P < 0.05). This group ...
The present study examined the effects of acute nutritional TD on remitted depressed patients currently treated with selective serotonin reuptake inhibitors. In an attempt to clarify conflicting earlier findings, the effects of a number of clinical variables on outcome were also investigated. METHODS: ...