Additionally, elevated tryptase levels in bronchoalveolar lavage fluid of asymptomatic, atopic persons with asthma suggest ongoing mast cell activation, which may relate to adenosine hyperresponsiveness and a persistence of bronchial hyperreactivity. Tryptase levels in bronchial lavage fluid of atopic patients...
Tryptase and chymase immunolocalization techniques have been used to examine the distribution, activation, and tryptase/chymase phenotype of mast cells (MC... Jeziorska,M. - 《Biology of Reproduction》 被引量: 406发表: 1995年 Mast cell and eosinophil distribution and activation in human endometrium...
Mast cells immunologically stimulated with IgE/Anti IgE had no further effects on fibroblast migration. Conclusions Mast cells and the mast cell mediator tryptase may have crucial roles in inducing lung fibroblast migration via PAR-2 activation, which may contribute to remodeling processes in chronic ...
The objective in this study was to investigate the effects of mast cells and specifically mast cell tryptase on fibroblast migration and the role of PAR2 activation.关键词: Human lung fibroblast, Lung, Mast cell, Migration, Protease activated receptor 2, Tryptase ...
Butrus et al., 1990, " The level of tryptase in human tears: an indicator of activation of conjunctival mast cells, " Ophthalmology 97:1678-1678-1683.Butrus SI,Ochsner KI,Abelson MB,et al.The level of tryptase in human tears: an indicator of activation of conjunctival mast cells[J]....
Results: Sixty-one percent of patients had extensive activation of mast cells in their middle ears. Among those with elevated tryptase in their effusion, 95.6% were atopic and 94.7% also had elevated effusion eosinophilic cationic protein. Tryptase was elevated only in the effusion of atopic ...
After activation mast cells release preformed mediators, e.g. histamine, heparin, tryptase, and produce prostaglandins, leucotriens, tromboxans and calicrein from the phospholipids of cell membranes. On addition many cytokines are released, e.g. IL-4, IL-5, IL-6, and TNF-α. It is thought...
Recent physiological and pharmacological studies have indicated the potential importance of tryptase, the major protein component in mast cells, in inflammatory diseases (especially asthma). Being released at inflammatory sites after the activation of mast cells, tryptase is capable of causing bronchohyperr...
The response to tryptase and the mast cell filtrate was inhibited by the tryptase inhibitor BABIM, and abolished by desensitization of PAR-2 with trypsin. PAR-2 activation inhibited the amplitude of rhythmic contractions of strips of rat colon. This response was unaffected by indomethacin, l-NG-...
Although there is relatively little evidence of inflammation in osteoarthritis (OA), increases in mast cell numbers and mast cell activation are prominent ... Mark G. Buckley,Patrick J. Gallagher,Andrew F. Walls - 《Journal of Pathology》 被引量: 48发表: 2015年 ALTERATIONS IN MAST CELL PROTEI...