Trypsinogen is an inactive precursor of the enzyme trypsin, produced in the pancreas and activated by enterokinase in the small intestine. AI generated definition based on:Olives and Olive Oil in Health and Disease Prevention,2010 About this page ...
Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback. Trypsin: The pancreas releases trypsinogen, an inactive precursor of trypsin, which is activated in the small intestine. Jillian Kubala, Health, 8 Aug. 2024 Word...
(Biochemistry) the inactive precursor of trypsin that is converted to trypsin by the enzyme enterokinase Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014 ...
Bovine Proenteropeptidase Is Activated by Trypsin, and the Specificity of Enteropeptidase Depends on the Heavy Chain Enteropeptidase, also known as enterokinase, initiates the activation of pancreatic hydrolases by cleaving and activating trypsinogen. Enteropeptidase is s... D Lu,X Yuan,X Zheng,.....
fail-safe, auto-destruction site of the trypsin molecule that normally is regulated by calcium. Patients with certain trypsinogen mutations develop recurrent AP, because activated trypsin cannot be controlled, and, when trypsinogen is activated prematurely within the pancreas at levels that exceed other...
In the early stage of acute pancreatitis, trypsinogen in acinar cells is activated, and the cells clear trypsin through zymophagy to avoid damage. Studies have shown that the substrate of zymophagy is ubiquitinated pancreatin, but the mechanism of pancre
More than a century ago, a German pathologist noted at autopsies of patients who had succumbed to acute pancreatitis that their intrapancreatic digestive enzymes had been activated.1 His fateful observation engendered the surprisingly long-lived belief that pancreatitis is an autodigestive phenomenon ...
Auto-digestion of the pancreas by its own prematurely activated digestive proteases is thought to be an important event in the onset of acute pancreatitis. Although lysosomal hydrolases, such as cathepsin B, play a key role in intrapancreatic trypsinogen activation, it remains unclear where and how...
stained with Coomassie Blue. A representative gel from two experiments is shown. Full size image Both ferret trypsinogen isoforms were readily activated by cathepsin B, the lysosomal cysteine protease responsible for intra-pancreatic trypsin activation in secretagogue-induced models of experimental acute ...
More than a century ago, a German pathologist noted at autopsies of patients who had succumbed to acute pancreatitis that their intrapancreatic digestive enzymes had been activated.1 His fateful observation engendered the surprisingly long-lived belief that pancreatitis is an autodigestive phenomenon ...