The present disclosure provides FGF19 mutant proteins, such as those having an N- terminal deletion, point mutation(s), or combinations thereof, which can reduce serum bile acids and/or blood glucose in a mammal. Such mutant FGF19 proteins can be part of a chimeric protein that includes a ...
Alzheimer’s A β peptides with disease-associated NTerminal modifications: Influence of isomerisation, truncation and mutation on Cu 2+ coordination. PLoS ... SC Drew,CL Masters,KJ Barnham - 《Plos One》 被引量: 53发表: 2010年 Alzheimer's Aβ Peptides with Disease-Associated N-Terminal Mo...
The purpose of this work is to show how mutation, truncation, and change of temperature can influence the folding kinetics of a protein. This is accomplished by principal component analysis of molecular-dynamics-generated folding trajectories of the triple β-strand WW domain from formin binding pr...
We describe three novel mutations (E177X, 323delT, 1313delTC), and report one recurrent mutation (R267X) in CHM. We believe this to be the first attempt at applying RT-PCR-PTT to CHM mutation detection. 展开 关键词: choroideremia mutation detection protein truncation test ...
SNC-Fc mutation and truncation Two fragments containing the binding sites within EC1 and EC4 were subcloned to facilitate polymerase chain reaction (PCR) mutagenesis. The first contained the HAV and INPISGQ motifs, which are required for interaction with N-cadherin,9 and was removed from SNC-Fc...
In 45 patients from breast and/or ovarian cancer families we found six novel mutations: two single nucleotide insertions, three small deletions (1–5 bp) and a nonsense mutation identified two unrelated families. Furthermore, we were able to amplify the remaining coding region by RT–PCR using...
geometry- the pure mathematics of points and lines and curves and surfaces interchange,substitute,replace,exchange- put in the place of another; switch seemingly equivalent items; "the con artist replaced the original with a fake Rembrandt"; "substitute regular milk with fat-free milk"; "synonyms...
A mutation that eliminates 177 nucleotides (d177) encoding 59 amino acids including the polyQ and polyproline (polyP) domains without frameshift was able to reach homozygosity (Fig.1c). Genotyping showed that this mutation reduces exon 1HTTDNA size (Supplementary Fig.2a), confirming the in-frame...
We have therefore studied the effect of a C_A mutation at this site within PAG in a Jurkat T-cell line, using both biochemical and functional assays. While the CxxC mutant is localized to the membrane, it does not target to the GEMs. However it becomes Tyr phosphorylated, binds Fyn, ...
Ophthalmologic information was collected for study subjects with primary open-angle glaucoma and their relatives. Mutation screening of 74 primary open-angle glaucoma probands was conducted by...关键词: Humans Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 5 Hypersensitivity, Immediate ...