TRPP2polycystin-2vascular smooth muscle cellendothelial cellhypertensionautosomal dominant polycystic kidney disease (ADPKDTRPP2 (polycystin-2, PC2 or PKD2), encoded by thePKD2gene, is a non-selective cation channel with a large single channel conductance and high Ca2+permeability. In cell membrane,...
本研究分为以下两部分来阐明TRPP2与STIM1之间的关系和在高血压发病中的作用:(1)TRPP2和STIM1存在相互作用调节SOCE并参与调节血管平滑肌细胞的收缩;(2)TRPP2-STIM1复合物在高盐饮食高血压大鼠血管平滑肌细胞表达改变及对其血压调节的影响.通过本课题研究,可以提供新的高盐饮食诱导的高血压病治疗的靶点,为临床进一步...
China; 2Department of Gastroenterology and Hepatology, The Fourth Affiliated Hospital of Anhui Medical University, Hefei 230032, China TRPP2 (polycystin-2, PC2 or PKD2), encoded by the PKD2 gene, is a non-selective cation channel with a large single channel conductance and high Ca2+ permeability...
In addition, shRNA knockdown of TRPP2 increased the prevalence of TRPV4 channel activity while knockdown of TRPV4 resulted in TRPP2 activity and knockdown of both proteins vastly decreased the 23-pS channel activity. Epidermal growth factor (EGF) stimulated TRPP2\TRPV4 channel through the EGF ...
TRPP2 and TRPV4 Form an EGF-Activated Calcium Permeable Channel at the Apical Membrane of Renal Collecting Duct Cells DOI: 10.1371/journal.pone.0073424 Zhi-Ren Zhang, Wen-Feng Chu, Binlin Song, Monika Gooz, Jia-Ning Zhang, Chang-Jiang Yu, Shuai Jiang, Aleksander Baldys, Pal Gooz, Stacy ...
呐,想装碟刹公路,机..呐,想装碟刹公路,机械油碟手变头太大,不喜欢,trp的这两款怎么样(不是p2的线碟),有什么区别,呐呐呐呐呐呐呐呐呐呐呐呐别推电变,电变碟刹太贵
TRPP2, a Ca2+-permeable non-selective cation channel, has been shown to negatively regulate cell cycle, but the mechanism underlying this regulation is unknown. Tumor necrosis factor α (TNF-α) is a proinflammatory cytokine extensively involved in immune system regulation, cell proliferation and ce...
The subjective feeling of cold is mediated by the activation of TRPM8 channels in thermoreceptive neurons by cold or by cooling agents such as menthol. Here, we demonstrate a central role for phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) in the activ
xx xx xxxx Differential PI(4,5)P2 sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels Juyeon Ko1, Jongyun Myeong1,2,Young-Cheul Shin3 & Insuk So1 Transient receptor potential canonical (TRPC) 4 and TRPC5 channels are modulated by the Gαq-PLC pathway...
The Molecular Determinants of PI(4,5)P2 Binding to TRPV1 ChannelsNot Availabledoi:10.1016/j.bpj.2014.11.698Poblete, HoracioOyarzún, IngridOlivero, PabloComer, JeffreyZu?iga, MatíasSepulveda, RominaBáez-Nieto, DavidGonzález, CarlosGonzalez-Nilo, Ferando...