TRPA1 and TRPM8 are transient receptor potential channels expressed in trigeminal neurons that are related to pathophysiology in migraine models. Here we use a mouse model of nitroglycerine-induced chronic migraine that displays a sexually dimorphic phenotype, characterized by mechanical hypersensitivity tha...
Notably, TRPM8 mRNA was also expressed in a number of nonprostatic primary tumors of breast, colon, lung, and skin origin, whereas transcripts encoding TRPM8 were hardly detected or not detected in the corresponding normal human tissues. 仅用于科研。不用于诊断过程。未经明确授权不得转售。
TRPM8 was identified originally as a prostate-specific gene [59], but was later found to be present in a subset of cold-responsive dorsal root ganglia neurons and in neurons from trigeminal ganglia [60,61]. Although the function of TRPM8 in the prostate is unknown, its presence in cold-...
研究发现,冷受体TRPM8是一种阳离子通道,广泛分布于哺乳动物皮肤和口腔中温度感受器细胞膜表面,可参与冷信号的传递。风油精中的薄荷醇能结合并激活TRPM8,使机体产生“凉爽”感觉。相关叙述正确的是( ) A. 皮肤涂抹风油精后,感受器细胞膜内外可发生电位变化 B. 皮肤涂抹风油精处,汗腺分泌活动增强,毛细血管舒张 C. ...
TRPM8受体是一种能够感知冷刺激的感受器,广泛分布于皮肤和口腔中。薄荷中的薄荷醇也能与TRPM8受体结合,让机体产生“冷“的感觉。下列叙述错误的是( ) A. 涂抹薄
TRPM8属于瞬时受体电位通道(transient receptor potential channel, TRP)超家族的一员,主要充当寒冷感受器,并且是薄荷醇、冰片等物质的作用靶点,受到磷酯酰肌醇二磷酸PIP2的调控。目前TPRM8已经成为治疗包括疼痛、癌症、肥胖症等多种疾病在...
TRPM8,是一种被证明可以被寒冷激活的受体。 我们之所以能感受到低温寒冷,全都仰仗于皮肤和口腔中的寒冷感受器,一种叫作TRPM8的神经受体。实际上,TRPM8受体还有另外一个名字——“寒冷与薄荷醇受体1”。从这个名字我们就可以看出,它最主要的功能是接收寒冷的温度刺激和薄荷醇的刺激,让机体产生冷的感觉。TRPM8是一类...
▲ TRPM8构象变化 总结与展望 该研究通过冷冻电镜技术观察TRPM8在不同条件下的结构,揭示TRPM8的一系列构象变化,确定TRPM8的关闭态和敏化态结构。研究表明TRPM8的脱敏是通过钙结合实现的,配体的结合区域具有可调节性。此外,TRPM8通道配体结合在S1~S4结构域中,在关闭态到...
15.研究发现,冷受体TRPM8是一种阳离子通道,广泛分布于哺乳动物皮肤和口腔中温度感受器细胞膜表面,可参与冷信号的传递。风油精中的薄荷醇能结合并激活TRPM8,使机体产生“凉爽”感觉。相关叙述正确的是 () A.皮肤涂抹风油精后,感受器细胞膜内外可发生电位变化 B.皮肤涂抹风油精处,汗腺分泌活动增强,毛细血管舒张 C.TRP...