lncRNA TRPC7-AS1miR-4769-5pnucleus pulposus cells (NPCs)Intervertebral disc (IVD) degeneration (IDD) is identified as an abnormal, cell-mediated, age-dependent and genetics-dependent molecular degeneration process in which NPCs (nucleus pulposus cells) senesce and the balance of ECM (extracellular ...
(lncRNA) has been confirmed as a key regulator of hepatocellular carcinoma occurrence. However, the function of TRPC7-AS1 has not been verified in hepatocellular carcinoma. The research results revealed that highIGF2BP2expression was associated with a decreasedsurvival ratein patients with ...
TRPC7-AS1 silencing repressed and its overexpression promoted the progression of hepatocellular carcinoma. After silencing or overexpressing TRPC7-AS1, the expression of the high-mobility group AT-hook 2 (HMGA2) gene decreased or increased, respectively. IGF2BP2 enhanced the expression of TRPC7-AS1...
本发明的研究表明lncRNATRPC7AS1在肝癌癌组织和在癌旁组织中的表达存在显著差异,且改变lncRNATRPC7AS1可以调控肝癌细胞增殖.发现lncRNATRPC7AS1受调控IGF2BP2,RNA甲基化酶METTL3通过介导lncRNATRPC7AS1的甲基化修饰促进肝癌的发生,发展.抑制lncRNATRPC7AS1及其甲基化水平,可以抑制肝癌的肿瘤进程,lncRNATRPC7AS1可...