Canonical transient receptor potential‐6 (TRPC6) channels have been implicated in the progression of several forms of kidney disease (1). While there is strong evidence that glomerular TRPC6 channels are dysregulated in diabetic nephropathy (DN), there is no consensus as to whether deletion or ...
with TRPC3 and TRPC7. It is primarily expressed in brain, lung and muscle. High levels of expression of the channel were also found in human platelets. Recently it was reported that TRPC6 is also expressed in the kidney where a mutated channel has been implicated in kidney failure disease....
Physiological roles of TRPC6 have been extensively studied in the kidney, but both constitutively active and dominant negative mutants of TRPC6 exacerbated renal dysfunctions20. This implies that TRPC6 contributes to both adaptive and maladaptive responses against environmental stress. In this study, we...
TRPC6 is a Ca2+-permeable non-selective cation channel expressed in brain, smooth muscle containing tissues and kidney, as well as in immune and blood cells. Channel homomers heterologously expressed have a characteristic doubly rectifying current-voltag
Novel Pathogenic Mutation of P209L in TRPC6 Gene Causes Adult Focal Segmental Glomerulosclerosis doi:10.1007/s10528-023-10651-yFOCAL segmental glomerulosclerosisGLOMERULOSCLEROSISWNT signal transductionKIDNEY failureCELL deathFocal segmental glomerulosclerosis (FSGS) is a leading ...
Injury to podocytes is considered a major contributor to diabetic kidney disease: their loss causes proteinuria and progressive glomerulosclerosis. Podocyte depletion may result from improper calcium handling due to abnormal activation of the calcium permeant TRPC (Transient Receptor Potential Canonical) chann...
Mutations in genes encoding structural proteins of the podocyte lead to the development of proteinuria, resulting in progressive kidney failure and focal segmental glomerulosclerosis. Here, we show that the canonical transient receptor potential 6 (TRPC6) ion channel is expressed in ...
A new TRP to kidney disease Now, new studies show that mutations in the cation channel TRPC6 underlie this hereditary kidney disorder and establish a molecular link between TRPC6 and... Gudermann,Thomas - 《Nature Genetics》 被引量: 72发表: 2005年 2-Aminoethoxydiphenylborane is an acute inhi...
contribution to podocyte injury Conclusion:the Wnt/13・ catenin signalling pathway may potentially be active in pathogenesis of TRPC6-mediated diabetic podocyte inJur), Key words:podocytes,Wnt/lB-catenin signalling pathway transient receptor potential cation channel protein 6,diabetes,kidney disease,high...
SOCE is mainly mediated by ORAI, a calcium channel in the plasma membrane, and stromal interaction molecules (STIM), an ER calcium sensor [13–16]. Dysregulation of SOCE is linked to neurological disorders such as Alzhei- mer's disease, Huntington's disease, and Parkinson's dis- ease [12...