TRPC3, TRPC6 molecules, as non-selective cation channels on the cell membranes, are involved in the processes. This review illustrated the functions of TRPC3 and TRPC6 on myocardial cells, smooth muscle cells and inflammatory cells in the development of hypertension, and the effects of drugs ...
而TRPC通道除了6次跨膜螺旋构成的孔道区以外,还具有较大的胞内N端结构域及C端结构域,这些结构域是如何参与组装TRPC通道四聚体的仍不为人知。 张小林博士首先开发了针对TRPC6通道的高亲和力抑制剂,陈雷研究组通过冷冻电镜技术解析了TRPC6通道与抑制剂复合物的分辨率为3.8Å的结构,同时也解析了TRPC3通道分辨率为4.4...
而TRPC通道除了6次跨膜螺旋构成的孔道区以外,还具有较大的胞内N端结构域及C端结构域,这些结构域是如何参与组装TRPC通道四聚体的仍不为人知。 张小林博士首先开发了针对TRPC6通道的高亲和力抑制剂,陈雷研究组通过冷冻电镜技术解析了TRPC6通道与抑制剂复合物的分辨率为3.8Å的结构,同时也解析了TRPC3通道分辨率为4.4...
Knockdown of TRPC6, but not TRPC3, enhanced basal expression levels of cytokines in rat cardiomyocytes. TRPC6 could interact with Nox2, but the abundance of TRPC6 was inversely correlated with that of Nox2. These results strongly suggest that Nox2 destabilization through disrupting TRPC3-Nox2 ...
TRPC3/6/7 通道参与多种神经活动,例如 TRPC3 在中枢神经系统高表达,参与神经生长因子 BDNF 信号转导5,同时 TRPC3 还与神经突触信号传递以及运动协调有关6,7。TRPC6 通道可以促进神经元存活以及兴奋性突触的形成等8,9。除此之外,TR...
TRPC3 and TRPC6 channels are calcium-permeable non-selective cation channels that are involved in many physiological processes. The gain-of-function (GOF) mutations of TRPC6 lead to familial focal segmental glomerulosclerosis (FSGS) in humans, but their pathogenic mechanism remains elusive. Here, we...
Ca2+ entry seen after carbachol treatment in cells transiently expressing TRPC1, TRPC3, TRPC5 or TRPC6 was not enhanced by the co-expression of STIM1... Wayne,I.,DeHaven,... - 《Journal of Physiology》 被引量: 340发表: 2009年 Antagonistic Regulation of Actin Dynamics and Cell Motility ...
据此推测,TRPC3,TRPC6通道可能在TSC致痫病灶中表达异常,并可能与TSC导致的癫痫发作密切相关,而相关研究还少见报道.为此,本研究采用Western blot,免疫组化及免疫荧光双标首先检测TRPC3,TRPC6通道在非结节性硬化,非癫痫患者的正常皮层脑组织中的表达情况,并与之做对照,观察TRPC3,TRPC6通道在结节性硬化症癫痫患者病灶...
不同降压药物干预对自发性高血压大鼠主动脉TRPC3及TRPC6表达的影响 目的本研究旨在了解雷米普利,缬沙坦和氨氯地平对自发性高血压大鼠(SHR)主动脉(内膜及平滑肌)的瞬时受体电位通道C亚族3亚型及6亚型(TRPC3,TRPC6)表达的影响.方法采用灌... 廖雪艳,陈明,余冬梅 - 中国南方国际心血管病学术会议 被引量: 0发表...