TRPC6 gene promoter polymorphisms in steroid resistant nephrotic syndrome childrenIntroduction Nephrotic syndrome (NS) is the most frequent cause of proteinuria in children and is emerging as a leading cause of uremia. Among idiopathic NS, % of children do not respond to steroids or to any other ...
Trichoderma reesei）的表达载体，需要用到抗性筛选标记。我想用来自Aspergillus nidulans的 trpC promoter，...
nature publishing group Basic Science Investigation Articles 254C>G: a TRPC6 promoter variation associated with enhanced transcription and steroid-resistant nephrotic syndrome in Chinese children Xin-Yu Kuang1, Wen-Yan Huang2, Hong Xu1, Yu Shi1, Xiu-Ling Zhang1, Xiao-Ling Niu2, Ying Wu2, ...
A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. A functional singlenucleotidepolymorphism in the TRPC6 gene promoterassociated with idiopathic pulmonary arterial hypertension [J].Circulation, 2009, 119(17): ... Y Yu,SH Kel...
Mechanistic studies involving PASMC showed that the TRPC6 promoter contains a binding site for peroxisome proliferator-activated receptor γ (PPARγ) and the NF-κB subunit p65. Interestingly, these factors exhibit opposing roles in the context of PAH. In hypoxic conditions, NF-κB/p65 competes wit...
(Mecp2 mutant mice) shows a loss of function of TRPC3 in hippocampus neurons that leads to sensory and motor abnormalities41. Increased TRPC6 promoter activity and TRPC6 expression have been linked to the development of idiopathic pulmonary arterial hypertension, which is caused by excessive ...
Although the binding site is not in the promoter region, we found that the expression of Trpc1 is dependent on TRα1 and T3, which strongly indicated a direct regulation of T3 and TRα1 on Trpc1 expression. That is also the underlying mechanisms of the chronic or “genomic” effects of...
A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation. 2009;119:2313–22. Article CAS PubMed Central PubMed Google Scholar Palatini P, Ceolotto G, Dorigatti F, Mos L, Santonastaso M, Bratti P, et al. ...
et al. Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells. Br J Cancer 108, 2005–2012, doi: 10.1038/bjc.2013.188 (2013). 14. Baguley, B. C. Tumor stem cell niches: a new functional framework for ...
Dtpiroeontte,ertinhmevincaoraidtaiinontngHoinyffPionerrtm4ra8acwteioallsnuslfuaobrrcHtlho2enOHe2d2iOunn2M-dseLerEntCshi.teiFvcoeor,neitnnrtohrlaaoncefcletlhudelyaEerlFHlo-12wOαf2leundoehrtaeensccc-eenr/t promoter into the pWPXL plasmid (distributed by Addgene, Boston) and packed with a...