大家好,今天给大家分享的文章是2018年发表在Clinical Cancer Research上名为Reimagining IDO pathway inhibition in cancer immunotherapy via downstream focus on the tryptophan- kynurenine -aryl hydrocarbon axis的综述。文章的通讯作者是...
[5] Liu D, Liang CH, Huang B, et al. Tryptophan Metabolism Acts as a New Anti-Ferroptotic Pathway to Mediate Tumor Growth. Adv Sci (Weinh). 2023 Feb;10(6):e2204006. [6] Becker C, Adolph TE. Disentangling tryptophan metabolism in inflammatory bowel diseases. Gut. 2023 Jan 3:gutjnl...
Objective To study the effects of Peiyuan Jieyu Formula (PYJYF) on rats treated with glucocorticoid ,its influences on metabolism of the TRP-KYN pathway and the impacts on hippocampal and cortical neuronal plasticity. Methods 70 rats were randomly divided int...
目的:研究培元解郁方的抗抑郁作用及其对色氨酸(Tryptophan,TRP)-犬尿氨酸(Kynurenine,KYN)途径的调节.方法:急性应激造成小鼠抑郁模型,采用Noldus EthoVision XT9系统采集分析小鼠强迫游泳不动时间,采用HPLC-MS/MS技术检测脑组织色氨酸、犬尿氨酸含量,实时荧光定量PCR检测肝组织中色氨酸2,3-双加氧酶(Tryptophan 2,3...
[5] Liu D, Liang CH, Huang B, et al. Tryptophan Metabolism Acts as a New Anti-Ferroptotic Pathway to Mediate Tumor Growth. Adv Sci (Weinh). 2023 Feb;10(6):e2204006. [6] Becker C, Adolph TE. Disentangling tryptophan metabolism in inflammatory bowel diseases. Gut. 2023 Jan 3:gutjnl...
InflammationPathogenesisTryptophan-Kynurenine PathwayMetabolomicsBackground HIV-1 has well-established mechanisms to disrupt essential pathways in people with HIV, such as inflammation and metabolism. Moreover, diversity of the amino acid sequences in fundamental HIV-1 proteins including Tat and Vif, have...
结论 培元解郁方可以通过下调TRP-KYN代谢,抑制神经毒性,提高神经保护;通过促进皮层和海马尤其是皮层的神经元可塑性发挥抗抑郁作用.%Objective To study the effects of Peiyuan Jieyu Formula ( PYJYF) on rats treated with glu-cocorticoid, its influences on metabolism of the TRP-KYN...
The Effect of Body Mass Index on the KYN/TRP Pathway in the Pathogenesis of Periodontitisdoi:10.52037/eads.2023.0025Güney, ZelihaAltngz, Sema MerveEuropean Annals of Dental Sciences
hippocampus were increased while the GFAP expression was decreased significantly in the model group.Conclusion:The modified Wendan decoction may improve the neurotrophic function of rats'hippocampal astrocytes by enhancing the neuroprotective function of the TRP-KYN pathway,thereby exerting an antidepressant ...