Instead, quantum mechanical ground state isosurfaces reveal variations in indole 蟺 electron distribution and density that parallel charge (as a function of pK1, pK2, and pKR) on the backbone and residues. A pattern of aromaticity-associated quantum yield and fluorescence lifetime changes emerges....
The TRPV subfamily (vanilloid receptors) comprises channels critically involved in nociception and thermosensing (TRPV1, TRPV2, TRPV3, and TRPV4), whereas TRPV5 and TRPV6 are involved in renal Ca(2+) absorption/reabsorption. Apart ... J.,Vriens,G.,... - 《Molecular Pharmacology》 被引量...
1 谷氨酸的pK1(α-COOH)=2.19,pK2 (α-NH+3 ) = 9.67,pKR(R基)= 4.25,谷氨酸的等电点为___.2 写出下列符号的中文名称:Tyr ___ ,Trp___,ATP___.3 蛋白质在紫外光___nm处有强的光吸收,核酸在紫外光___nm处有明显的光吸收.蛋白质的平均含氮量是___.4 由非糖物质生成葡萄糖或糖元的作用...
(TRPV1) is present in the kidney and acts as a renal sensor. However, the mechanism underlying IS-mediated renal tubular damage in view of TRPV1 is lacking. Here, we demonstrated that TRPV1 was expressed in tubular cells of Lilly Laboratories cell-porcine kidney 1 (LLC-PK1) and Madin...
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In this study, we explored the effect of external Ca2+ on endogenous PC2 in wild type LLC-PK1 renal epithelial cells. We obtained whole cell currents at different external Ca2+ concentrations, and observed that the basal whole cell conductance in normal Ca2+(1.2 mM), decreased by 30.2% in...
We find that the change in free energy difference due to the protonation of the Asp amino acid is 3 kJ mol1at 297 K, favoring the charged state, and resulting in 螖pK1= 0.5 units for Asp9. We also study the differences in the unfolded state ensembles for the two charge states and ...