TRPM2 ion channel promotes gastric cancer migration, invasion and tumor growth through the AKT signaling pathway Sci Rep, 9 (2019), p. 4182 Google Scholar 136 L. Liu, N. Wu, Y. Wang, X. Zhang, B. Xia, J. Tang, et al. TRPM7 promotes the epithelial-mesenchymal transition in ovarian...
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kappa-light-chain-enhancer of activated B cells; NFAT, nuclear factor of activated T-cells; PDGF, platelet-derived growth factor; PI3K, phosphatidylinositol-3-kinases; STAT, signal transducer and activator of transcription; Tat, transactivator of transcription (toxin); TGF, transforming growth factor...
Lactate inhibits TRPV1-mediated membrane currents evoked by different agonists at pH 7.4. We next explored if LA inhibits activation of TRPV1 by capsaicin (CAP) or heat at neutral pH-values (pH 7.4). Considering that LA is a weak acid causing substantial acidosis upon accumulation, ...
Cap, 3 mg/kg capsaicin. Average values represent the mean ± SEM. *P < 0.05, **P < 0.01 versus control (Tukey’s test after one-way ANOVA). #P < 0.05, ##P < 0.001 versus WT-HI (Tukey’s test after one-way ANOVA) Full size image To investigate whether TRPV1 is involved in...
a, b Representative traces for currents at −60 mV evoked by increasing concentrations of capsaicin (Cap) as indicated for CHO-K1 cells that expressed Flag-tagged rat TRPV1 (Flag-TRPV1) (a), Flag-TRPV1+GFP-SUMO1+Ubc9 (b), Flag-TRPV1-K822R (c), and Flag-TRPV1-K822R+GFP...
Cell-free adipose tissue extracts (ATEs) are liquid components extracted from human adipose tissue that contain large amounts of growth factors. Despite the scar-reducing, anti-aging, and wound-healing effects of ATEs, the efficacy of ATEs in rosacea remains unknown. Therefore, the anti-rosacea ...
The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated. Here we report t
n=11, WT 1 μM cap. n=9, WT 1 μM cap.+ 1 μM SB n=12, WT 1 μM SB n=12, TRPV1 KO control n=9, TRPV1 KO 1 μM cap. n=9; from 5 cultures. Error=s.e.m., significance determined by one-way ANOVA with Tukey's post hoc test for multiple comparisons,...