Turkey) and their stock solutions were prepared in dimethyl sulfoxide. After diluting in extracellular solution, and the pH adjustments of the ACA, 2-APB, ADPR and hydrogen peroxide (H2O2), they were freshly incubated with the cells.
However, the exact mechanism of how TRMP2 deletion decreases HPDs needs further investigation. The IHKA model of TLE we used in our experiment has greatly contributed to the understanding of the molecular, cellular and pharmacological mechanisms underlying epileptogenesis (Levesque and Avoli, 2013)....
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LA-induced inhibition of pH5.4-evoked inward currents was cAaslcius ldaetemdotnos0tr.7a t±ed 0.i1n mFMig. (1nB =, t 5h–e7ICfo5r0-evaaclhuecofnor- centration, Hill coefficient 0.9 ± 0.07). Thus at 2 mM, closely matching the physiological plasma ...
Stock solutions of the compounds of 10 mM in DMSO were stored in small aliquots at −80°C. The assay protocols for both TRPML3 and TRPN1 were identically matched. Cells were diluted in growth medium and dispensed into 1536-well black-wall, clear-bottom plates (Greiner Bio-One) at a ...
Upur H, Yusup A, Baudrimont I, Umar A, Berke B, Yimit D, Lapham JC, Creppy EE, Moore N: Inhibition of cell growth and cellular protein, DNA and RNA synthesis in human hepatoma (HepG2) cells by ethanol extract of abnormal Savda Munziq of traditional Uyghur medicine. Evid Based Comple...
The overexpression of TRPV1 in intestinal epithelial HCT116 cells suppressed the phosphorylation of epidermal growth factor receptor (EGFR) at Y1068, a receptor that is associated with a variety of pro-proliferative signaling pathways [70]. According to the results of in vitro studies, the depleti...
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Autophagy is regulated by many factors including glucose, growth factors, amino acids, or starvation and energy status. The elimination of unwanted protein aggregates and damaged organelles is essential to avoid cell damage, e.g. damage to neurons and other brain cells, resulting eventually in a ...
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