I've only used Proton Experimental due to other ProtonDB suggestions (Native might work well but no reason to test it). You may need to rename the "Launcher" folder located at ../steam/steamapps/common/Tropico 6/Launcher/ to disable the default launcher. Game works very well with minimal...
Tinker Steps:Switch to older version: 7.0-6 Windowing:Switching I used Proton 7.0.6 because it's a limitation for my OS (steam would not run Proton 8 on Vulkan 1.2). You can use controller to play it if you like (it fully works on default layout). The only issue is inability to ...