Funding support for the Wistar Institute core facilities was provided by a Cancer Center Support Grant (P30 CA010815). Author information Authors and Affiliations Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA Kelsey L. Swingle, Alex G. Hamilton, Hannah C. Safford,...
Cancer Lett 239: 10–20 CAS PubMed Google Scholar Feld JJ, Hoofnagle JH (2005) Mechanism of action of interferon and ribavirin in treatment of hepatitis C. Nature 436: 967–72 CAS PubMed Google Scholar Gerlich WH (2006) Breakthrough of hepatitis B virus escape mutants after vaccination...
We then analyzed TfR1 protein levels in clinical NPC tissues. TfR1 exhibited strong cell surface expression in 174 NPC cases but remarkably weaker expression in 98 cases of non-cancerous nasopharyngeal epithelium (NNE) tissues (Fig.1e, f). Moreover, TfR1 expression in NPC tissues was signific...
HER2+ breast cancer patients are presented with either synchronous (S-BM), latent (Lat), or metachronous (M-BM) brain metastases. However, the basis for disparate metastatic fitness among disseminated tumor cells of similar oncotype within a distal organ remains unknown. Here, employing brain meta...
Clarified viral supernatant were analyzed by p24 ELISA (AIDS and Cancer Virus Program NCI-Frederick, MD, USA) for HIV-1 p24 antigen concentration and infectivity of virus stocks also compared using TZMBL indicator cells. Virus like particles containing Vpx were prepared as previously described [36...
Epstein-Barr virus (EBV) is a causative agent of infectious mononucleosis and is associated with 200,000 new cases of cancer and 140,000 deaths annually. Subunit vaccines against this pathogen have focused on the gp350 glycoprotein and remain unsuccessful. We isolated human antibodies recognizing th...
PNI describes the process of cancer cells invading the nerve, crossing all layers of the nerve sheath. Once the cancer cells are invaded in the nerve, they have reached a favorable environment to travel intraneural and contribute to the progression of the disease. Over time different definitions...
Recombinant adeno-associated viruses (rAAVs) are currently considered the safest and most reliable gene delivery vehicles for human gene therapy. Three serotype capsids, AAV1, AAV2, and AAV9, have been approved for commercial use in patients, but they ma
A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells. Sci. Rep. 2015, 5, 13543. [Google Scholar] [CrossRef] [PubMed] [Green Version] Zielonka, J.; Joseph, J.; Sikora, A.; Hardy, M.; Ouari, O.; Vasquez-Vivar, J.; Cheng, G.; Lopez,...