Rna BiologyG. Martinez, tRNA-derived small RNAs: new players in genome protection against retrotransposons, RNA Biol. (2017), http://dx.doi.org/10.1080/15476286.2017. 1403000.Martinez, G. (2018) tRNA-derived small RNAs: New players in genome protection against retrotransposons. RNA Biology 15,...
et al. A tRNA-derived small RNA regulates ribosomal protein S28 protein levels after translation initiation in humans and mice. Cell Rep. 29, 3816–3824.e4 (2019). The authors unravel a crucial function of tdRs in directing mRNA translation through changes in the secondary structure of ...
Roles and regulation of tRNA-derived small RNAs in animals Sowndarya Muthukumar Cai-Tao Li Cristian Bellodi Nature Reviews Molecular Cell Biology(2024) Identification of serum tsRNA-Thr-5-0015 and combined with AFP and PIVKA-II as novel biomarkers for hepatocellular carcinoma ...
50, No. 3 https://doi.org/10.1093/nar/gkac022 Published online 20 January 2022 Dicer dependent tRNA derived small RNAs promote nascent RNA silencing Arianna Di Fazio†, Margarita Schlackow†, Sheng Kai Pong†, Adele Alagia and Monika Gullerova * Sir William Dunn ...
tRNA-derived Small RNAs(tsRNAs):New Player in Physiological and Disease Conditions By small RNA deep sequencing,we recently revealed that the mature sperm contain a unique subset of highly enriched small RNA families derived from 5'halves... Qi,Chen,Enkui,... - 中国国际生物医药创新与合作大会暨...
Small non-coding RNAs play critical regulatory roles in post-transcription. However, their characteristics in Trichomonas vaginalis, the causative agent of human sexually transmitted trichomoniasis, still remain to be determined. Methods Small RNA transcriptomes from Trichomonas trophozoites were deep sequenced...
‘tRF-Browser’showsboththesitesoforiginandthedistri-butionofchemicalmodificationsitesintRFsontheirsourcetRNA.ThetRF2Cancerwebserverisavailableathttp://rna.sysu.edu/tRFfinder/.INTRODUCTIONtRNA-derivedsmallRNA ragments(tRFs)areonegroupo smallnon-codingRNAsderived rommatureorpre-cursortrans erRNAs(tRNAs...
现有证据充分证明siRNA, miRNA, piRNA, 等经典sncRNA在基因转录后调控以及多种疾病发生过程中起着重要的作用。然而,随着测序技术和生物信息分析工具的进步,近年来学界逐步认识到在熟知的经典小RNA之外还存在大量其它类型的新型sncRNA,例如近年来发现的tRNA-derived small RNA (t...
In addition, augmented TyrGUA tRNA halves are produced in a tumor suppressor DIS3-like 3′-5′ exoribonuclease 2 (DIS3L2)-dependent manner and interact with the RNA-binding proteins heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) and small RNA-binding exonuclease protection factor La (SSB) ...
Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the roles of tsRNAs in the development of human diseases. However, our knowledge about tsRNAs is still relatively lacking. ...