Biomedical Engineering/BiotechnologyBioinformaticsCompanies advance tRNA therapeutics to overcome mutant stoppages in protein synthesis shared by thousands of genetic diseases and cancers.doi:10.1038/s41587-022-01252-yElie DolginSpringer NatureNature Biotechnology
tRNA therapeutics burst onto startup scene. Nat. Biotechnol. 40, 283–286 (2022). Article CAS PubMed Google Scholar Capecchi, M. R., Haar, R. A., Capecchi, N. E. & Sveda, M. M. The isolation of a suppressible nonsense mutant in mammalian cells. Cell 12, 371–381 (1977). ...
2022年2月24日,国际生物技术权威期刊《Nature Biotechnology》发表 “tRNA therapeutics burst onto startup scene”的新闻评论[1],讲述了tRNA疗法的全球研发历史及进展,其中包括北京大学药学院夏青教授开创性应用“tRNA-酶”治疗无义突变罕见病的...
基于这种融资热潮以及hC Bio最新的融资进展,Nature Biotechnology于近日发表了题为“tRNA therapeutics burst onto startup scene”的报道。 来源:Nature Biotechnology 始于40年前 作为mRNA翻译过程中的一种辅助性分子,tRNA携带着特定的氨基酸,通过反密码子与mRNA链上...
团队专注于研发“工程化tRNA-酶”来推进治疗肌营养不良症和无义突变引起的癌症。对于递送技术,科研人员强调,因为tRNA本身很小,所以不会像其他疗法一样受限于载体的载荷。 2022年2月24日,国际生物技术权威期刊Nature Biotechnology发表“tRNA therapeutics burst onto startup scene”的新闻评论[1],讲述了tRNA疗法的全球...
tRNA therapeutics burst onto startup scene. Nat Biotechnol (2022). https://doi.org/10.1038/s41587-022-01252-y; Restoration of dystrophin expression in mice by suppressing a nonsense mutation through the incorporation of unnatural amino acids. Nat Biomed Eng 6, 195–206 (2022).https://doi.org...
Dolgin, E. tRNA therapeutics burst onto startup scene. Nat Biotechnol 40, 283–286 (2022). https://doi.org/10.1038/s41587-022-01252-y Wang, J., Zhang, Y., Mendonca, C. A., Yukselen, O., Muneeruddin, K., Ren, L., Liang, J., Zhou, C., Xie, J., Li, J., Jiang, Z....
基于这种融资热潮以及hC Bio最新的融资进展,Nature Biotechnology于近日发表了题为“tRNA therapeutics burst onto startup scene”的报道。 来源:Nature Biotechnology 始于40年前 作为mRNA翻译过程中的一种辅助性分子,tRNA携带着特定的氨基酸,通过反密码子与mRNA链上的密码子结合,将对应的氨基酸转移到核糖体中,完成肽链...
3.https://www.genengnews.com/gen-edge/no-nonsense-alltrna-touts-trna-therapeutics-to-treat-thousands-of-diseases/ 4.Dolgin, E. tRNA therapeutics burst onto startup scene. Nat Biotechnol 40, 283–286 (2022). https://doi.org/10.1038/s41587-022-01252-y ...
Dolgin E. TRNA therapeutics burst onto startup scene. Nat Biotechnol. 2022;40:283–6. Article CAS PubMed Google Scholar Luo Y, Yao Y, Wu P, Zi X, Sun N, He J. The potential role of N(7)-methylguanosine (m7G) in cancer. J Hematol Oncol. 2022;15:63. Article CAS PubMed PubMed...