has been mutated into a premature termination or “stop” codon (PTC). This results in a truncated or absent protein that causes disease. Alltrna has engineeredtRNAs that can specifically read PTCs and deliver the desired amino acid, thereby restoring the production of the full-length ...
RNA modificationsstressDuring particular stress conditions, transfer RNAs (tRNAs) become substrates of stress-induced endonucleases, resulting in the production of distinct tRNA-derived small RNAs (tsRNAs). These small RNAs have been implicated in a wide range of biological processes, but how ...
2022年5月，中国科学院西北生态环境资源研究院刘光琇研究团队（一作：陈熙明副研究员）在Nucleic Acids Research期刊（IF:19.16）发表的题为 “A new bacterial tRNA enhances antibiotic production in Streptomycesby circumventing inefficient wobble base-pairing ”的研究成果，发现了一种新型tRNA，并通过iTRAQ...
2022年5月,中国科学院西北生态环境资源研究院刘光琇研究团队(一作:陈熙明副研究员)在Nucleic Acids Research期刊(IF:19.16)发表的题为“A new bacterial tRNA enhances antibiotic production in Streptomycesby circumventing inefficient...
2022年5月,中国科学院西北生态环境资源研究院刘光琇研究团队(一作:陈熙明副研究员)在Nucleic Acids Research期刊(IF:19.16)发表的题为“A new bacterial tRNA enhances antibiotic production in Streptomycesby circumventing inefficient wobble base-pairing ”的研究成果,发现了一种新型tRNA,并通过iTRAQ蛋白质组学...
2022年5月,中国科学院西北生态环境资源研究院刘光琇研究团队(一作:陈熙明副研究员)在Nucleic Acids Research期刊(IF:19.16)发表的题为“A new bacterial tRNA enhances antibiotic production in Streptomycesby circumventing inefficient wobble base-pairing ”的研究成果,发现了一种新型tRNA,并通过iTRAQ蛋白质组学...
Methods for evaluation of in vitro aminoacyl tRNA production using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry The present invention relates to a new use for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Specifically, the ...
(Fig. 2), which suggests a coordination between tRNA production and mRNA translation[4]. Overexpression of initiator tRNAi(Met) significantly alters the global tRNA expression profile and increases the cell metabolic activity and cell proliferation[5]. At the level of cytochrome c-mediated apopto...
2022年5月,中国科学院西北生态环境资源研究院刘光琇研究团队(一作:陈熙明副研究员)在Nucleic Acids Research期刊(IF:19.16)发表的题为“A new bacterial tRNA enhances antibiotic production in Streptomycesby circumventing inefficient wobble base-pairing ”的研究成果,发现了一种新型tRNA,并通过iTRAQ蛋白质组学...
2022年5月,中国科学院西北生态环境资源研究院刘光琇研究团队(一作:陈熙明副研究员)在Nucleic Acids Research期刊(IF:19.16)发表的题为“A new bacterial tRNA enhances antibiotic production in Streptomycesby circumventing inefficient wobble base-pairing ”的研究成果,发现了一种新型tRNA,并通过iTRAQ蛋白质组学...