Transfer RNA (tRNA) is an adapter molecule that links a specific codon in mRNA with its corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post-transcriptionally. A wide variety of tRNA modifications are found in the tRNA anticodon, which are crucial for precise codo...
tRNAs are key adaptor molecules that decipher the genetic code during translation of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously expressed housekeeping molecules, awareness is now growing that tRNA-encoding ge
MINTmap: fast and exhaustive profiling of nuclear and mitochondrial tRNA fragments from short RNA-seq data. Sci. Rep. 7, 41184. [PubMed: 28220888]Loher, P., Telonis, A. G. & Rigoutsos, I. MINTmap: fast and exhaustive profiling of nuclear and mitochondrial tRNA fragments from short ...
RNA, or ribonucleic acid, is a linear polymer of adenine, thymine, cytosine, and uracil that is created in the cell by a process called transcription, and it differs from DNA in several ways. First, the ribose sugars on DNA nucleotides are short one hydroxyl group compared to RNA, hence ...
This complex enters the ribosome, where tRNA with its an-ticodon interacts specifically with one of the codon triplets of the messenger RNA ( mRNA ). Subsequently, the amino acid is covalently bound to the C-terminus of a growing polypeptide chain. This short description of protein biosynthesis...
随后,在模板区域基于近缘种反 密码子环和反密码子臂进行人工手动查找[10],通过 分析 tRNA 基因反密码子,二级结构与它们的近缘 种核苷酸序列进行手动比对,确保其一级序列和二 级结构均高度保守.从 Vienna RNA 安装包(v2.3.3) 中使用 RNAeval 分别计算二级结构的最小自由能 (minimum free energy, MFE)[11],...
或 short interfering RNA （干扰RNA; siRNA）silencing RNA（沉默RNA si RNA）、spliceosome RNA （...
抑制基因tRNA抑制基因tRNA是在给定转译系统中,(例如)通过提供响应选择密码子而将氨基酸并入多肽链中的机制,来改变信使RNA(mRNA)的读取的tRNA。举例而言,抑制基因tRNA可读遍包括(但不限于)终止密码子、4碱基密码子或稀有密码子的密码子。 抑制活性术语“抑制活性”指的是例如抑制基因tRNA的tRNA读遍选择密码子的能力。
1C), the regulatory subunit of the m7G RNA methyltransferase complex [30, 31], which is also overexpressed in other cancers [22, 28, 29, 38, 39]; however, we did not find WDR4 overexpression to be a risk factor for poor prognosis (Fig. 1D; Supplementary Fig. S1C). Increased ...
GtRNAdb 2.0: an expanded database of transfer RNA genes identified in complete and draft genomes. Nucleic Acids Res. 44, D184–D189 (2016). Article CAS PubMed Google Scholar Johnson, P. F. & Abelson, J. The yeast tRNATyr gene intron is essential for correct modification of its tRNA ...