tRNAs are key adaptor molecules that decipher the genetic code during translation of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously expressed housekeeping molecules, awareness is now growing that tRNA-encoding ge
MINTmap: fast and exhaustive profiling of nuclear and mitochondrial tRNA fragments from short RNA-seq data. Sci. Rep. 7, 41184. [PubMed: 28220888]Loher, P., Telonis, A. G. & Rigoutsos, I. MINTmap: fast and exhaustive profiling of nuclear and mitochondrial tRNA fragments from short ...
GtRNAdb 2.0: an expanded database of transfer RNA genes identified in complete and draft genomes. Nucleic Acids Res. 44, D184–D189 (2016). Article CAS PubMed Google Scholar Johnson, P. F. & Abelson, J. The yeast tRNATyr gene intron is essential for correct modification of its tRNA ...
This complex enters the ribosome, where tRNA with its an-ticodon interacts specifically with one of the codon triplets of the messenger RNA ( mRNA ). Subsequently, the amino acid is covalently bound to the C-terminus of a growing polypeptide chain. This short description of protein biosynthesis...
RNA is a critical component of every single living cell in the universe. Without it, life as we know it could not exist. There are three types of RNA, each with a unique function. mRNA is used to produce proteins from genes. rRNA, along with protein, for
allows efficient transcription of shortRNAsand RNAs for which transcription is initiated at nucleotides other than G (such as tRNAiMet). Reaction mixtures are incubated at 37° for 1h, after which tRNA is extracted with acidic phenol/chloroform (pH 4.7) and ethanol-precipitated. tRNA transcripts ...
抑制性tRNA:抑制性tRNA是(例如)通过提供响应选择性密码子将氨基酸并入多肽链的机制来改变指定翻译系统中信使RNA(mRNA)的阅读的tRNA。举例来说,抑制性tRNA可通读例如终止密码子、四碱基密码子或稀有密码子等。 可重复利用tRNA:术语“可重复利用tRNA”是指在翻译期间经氨酰化且可利用氨基酸(例如非天然氨基酸)反复地再氨...
Here, we provide evidence for a novel gene silencing path- way mediated by Dicer dependent tsRNAs which is dis- tinct from PTGS or TGS. Notably, tsRNAs guide Ago2 proteins to target protein coding transcripts and long non- coding RNA in the nucleus leading to nascent R...
抑制基因tRNA抑制基因tRNA是在给定转译系统中,(例如)通过提供响应选择密码子而将氨基酸并入多肽链中的机制,来改变信使RNA(mRNA)的读取的tRNA。举例而言,抑制基因tRNA可读遍包括(但不限于)终止密码子、4碱基密码子或稀有密码子的密码子。 抑制活性术语“抑制活性”指的是例如抑制基因tRNA的tRNA读遍选择密码子的能力。
tRNA is the RNA type that undergoes the most modifications among known RNA, and in recent years, tRNA methylation has emerged as a crucial process in regulating gene translation. Dysregulation of tRNA abundance occurs in cancer cells, along with increased expression and activity of tRNA methyltransfe...