we developed a trispecific antibody that interacts with CD38, CD3 and CD28 to enhance both T cell activation and tumor targeting. The engagement of both CD3 and CD28 affords efficient T cell stimulation, whereas the anti-CD38 domain directs T cells to myeloma cells, as well as to certain lym...
MBS307 is a novel first in class PD-L1/PD-L1/CD40 tri-specific antibody that can promote CD40 agonist signaling in a PD-L1 dependent manner and simultaneously block PD-1/PD-L1 interaction. We developed eight multi-specific antibody formats to analyze its structure-activity relationship, and ...
Due to its multiple epitope binding, ABS-VIR-001 is more resistant to the viral antibody escape through mutations as a single mutation in the S1 structure would not completely lose its binding of ABS-VIR-0018. This would make it ideally suited to counter the emerging SARS-CoV-2 variants ...
The strategies of antibody humanization are based on the knowledge about distinguishable structure and distinct domain of antibody. Antibody is shaped like a capital letter “Y” and consists of two identical long “heavy” chains and two identical short “light” chains. Each chain has one variabl...
We developed a model generation code to create a template for the trispecific antibody model which can be easily altered to reflect the presence of different cells and different synapse combinations. The model generation code is a traversal algorithm for all actions and interactions between cells and...