This review describes the many and varied antibody-based building blocks used to achieve multivalency and multispecificity. These diverse building blocks provide opportunities to tailor the design of BsAbs and TsAbs to match the desired applications....
First-in-class trispecific VHH-Fc based antibody with potent prophylactic and therapeutic efficacy against SARS-CoV-2 and variantsAllison Titong, Sachith Gallolu Kankanamalage, Jianbo Dong, Betty Huang, Nicholas Spadoni, Bo Wang, Meredith Wright, Keegan L. J. Pham, Anh Hai Le & ...
Here we demonstrate that a trispecific antibody to HER2, CD3 and CD28 stimulates regression of breast cancers in a humanized mouse model through a mechanism involving CD4-dependent inhibition of tumour cell cycle progression. Although CD8 T cells directly mediated tumour lysis in vitro, CD4 T cells...
The present review discusses the pros and cons for the use of the Fc fragment during the development of bsAbs using either cell-fusion or recombinant DNA technologies. The recombinant antibody technology allows the generation of very efficient bsAbs containing no Fc domain such as the bi-specific...
2A). Each experiment demonstrated a different function of the antibody and could be used to inform different key subsets of model parameters and minimize uncertainty in these parameters. Two different model structures were used for optimization, to match the cells included and interactions represented ...