Steinhardt JJ, Guenaga J, Turner HL, et al. Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity. Nat Commun; 1-12.Steinhardt JJ, Guenaga J, Turner HL, McKee K, Louder MK, et al. (2018) Rational design of a trispecific antibody targeting...
ABS-VIR-001 was developed by the computer-aided antibody design (CAAD)7,8. This technology platform allows for faster screening of antibody candidates with higher probability of future clinical success. In addition, it allows the proper optimization of candidates to have a high efficacy, safety, ...
Our QSP model of the trispecific antibody aims to understand the specific mechanisms and effects of this drug, and to predict how the design of this novel therapy can provide advantages compared to standard TCEs. Our initial model was extensively calibrated to and validated with in vitro data ...
This review describes the many and varied antibody-based building blocks used to achieve multivalency and multispecificity. These diverse building blocks provide opportunities to tailor the design of BsAbs and TsAbs to match the desired applications....
Here, we design and characterize two novel antibodies, A-319 and A-2019. Blinatumomab and A-319 are CD3/CD19 bispecific antibodies with different molecular sizes and structures, and A-2019 is a novel CD3/CD19/CD20 trispecific antibody with an additional anti-CD20 function. Our in vitro, ex...
Recombinant fusion proteins were constructed using scMATCH3 technology and humanized antibody single-chain variable fragments against PD-L1, 4-1BB, and human serum albumin. Paratope affinities were optimized using single amino acid substitutions, leading to design of the drug candidate NM21-1480. ...
French, R. R. (1998). "Production of bispecific and trispecific F(ab)2 and F(ab)3 antibody derivatives." Methods MolFrench RR. Production of bispecific end trispecific F(ab)2 and F(ab)3 antibody de- rivatives. Methods Mol Biol 1998; 80: 121-134....
Production of Bispecif ic and Trispecific F(ab)2 and F(ab)3 Antibody DerivativesBispecific antibodies (BsAbs) are hybrid molecules designed to combine two antibodies with different specificities. This dual specificity has led to their application in a variety of diagnostic situations that require ...
1.A cyclic single-chain trispecific antibody against human tumor, comprising three parts connected together, a first part thereof having an anti-tumor fab antibody, an anti-tumor single-domain antibody or an scFv; a second part thereof having a reshaped fab antibody against human CD3, a reshape...
Recombinant fusion proteins were constructed using scMATCH3 technology and humanized antibody single-chain variable fragments against PD-L1, 4–1BB, and human serum albumin. Paratope affinities were optimized using single amino acid substitutions, leading to design of the drug candidate NM21-1480. ...