This study (NCT04728035) aimed to explore the safety and efficacy of liposomal irinotecan (HE072) in patients with metastatic triple-negative breast cancer (mTNBC). This study consisted of two parts. In part 1, the 3 + 3 design was used to investigate three dose levels of HE072 (50...
According to results of a study presented at the 14th Annual International Meeting of the ISPOR, recently held in Orlando, Florida, US, adding bevacizumab to an adjuvant chemotherapy regimen for patients with early triple-negative breast cancer ( TNBC ) provides short-term reductions in the risk ...
if the cancer hasn't spread too far. Triple-negative has a worse prognosis than other invasive breast cancers, and can grow and spread faster. It's also known to be more likely to come back after treatment.
Here, we aimed to evaluate the efficacy and safety of subtyping-based therapy in the first-line treatment of triple-negative breast cancer. Methods FUTURE-SUPER is an ongoing, open-label, randomised, controlled phase 2 trial being conducted at Fudan University Shanghai Cancer Center (FUSCC), ...
Triple-negative breast cancer is a rare type of breast cancer in which all receptor tests come back negative. It’s serious, but it responds well to treatment if you catch it early. Learn more about the symptoms, recurrence rate, life expectancy, and tre
Triple-negative breast cancer (TNBC) is one of the most aggressive forms of the disease and affects almost one in seven of the 1.5 million women diagnosed with breast cancer worldwide each year. TNBC tumors are missing three key proteins that can be targeted by conventional breast cancer therap...
Triple-negative breast cancer (TNBC) is a heterogeneous disease and lacks effective treatment. Our previous study classified TNBCs into four subtypes with putative therapeutic targets. Here, we report the final results of FUTURE, a phase II umbrella tria
Triple negative breast cancer, which represents approximately 15 percent of all breast cancer diagnoses, is considered by many experts the most deadly form of the disease. Because it tests negatively for estrogen and progesterone receptors, it is unresponsive to hormonal therapies. Recurrence is common...
However, the crosstalk between breast cancer cells and adipocytes has been given less attention compared to cancer-associated fibroblasts. We try to explain whether cancer associate adipocytes (CAAs) in microenvironment can lead to metabolic remodeling of triple-negative breast cancer, promoted cancer ...
Triple-negative breast cancerMajor depressive disorderImmune cell infiltrationPrognostic valueSingle-cell sequencingTNBC, the most aggressive form of breast cancer, lacks accurate and effective therapeutic targets. Immunotherapy presents a promising approach for addressing TNBC. Anxiety and depression are ...