MEK inhibitor resistancePD-L1 inhibitorsCMS4 gene expression signature in a preclinical model of colon cancer cells with acquired resistance to MEKi. Agilent microarray analyses were performed to assess baseline gene expression profile for SW48 and SW48-MR Colon cancer cell lines, as described in ...
Activating mutations of the genes involved in RAF-MEK1/2-ERK1/2 signaling are quite infrequent in TNBC, and only occur in<5% TNBC cases [26,73]. Ras/MAPK activity can be aberrantly stimulated via the overexpression of RTKs or copy number alterations ofKRASandBRAF. Also, loss of DUSP4 o...
Firstly, by qRT-PCR we demonstrated that, the transfection of cells with miR-34c or miR-449a mimics effectively up-regulates miR-34c and miR-449a transcriptional levels in the two TNBC cell lines reaching a value approximately double (data not shown). Next, to analyze the antitumor activity...
Minoru Akiyama et al., 2023, in their study, investigated the safety of high-dose kaempferol aglycone (a kaempferol derivative) in healthy adults in a randomized, double-blind, placebo-controlled study in which the participants were given either a daily 50 mg kaempferol aglycone or a placebo ...
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The addition of fulvestrant to the double combination showed a further trend in the reduction of this (p = 0.09) (Fig. 6f). Finally, assessment of fulvestrant alone or in combination with RAD001 showed no impact on EGFR/EGF-regulated genes; however, the addition of neratinib significantly ...
Methods In order to understand the mechanism underlying MEK inhibitor (MEKi) resistance, we generated three different MEKi resistant models, two all RAS WT (SW48-MR and LIM1215-MR) and one mutated in RAS (HCT116-MR). Results These models showed features related to the gene signature of ...
EGFR and MEK blockade in triple negative breast cancer cells. J Cell Biochem 2015;116:2778-85. https://doi.org/10.1002/jcb.25220.Maiello MR, D'Alessio A, Bevilacqua S, Gallo M, Normanno N & De Luca A 2015 EGFR and MEK blockade in triple negative breast cancer cells. ...
Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancerTNBC, PDGFRβ, JAK2, Resistance, CD8+ T cellBackgroundDespite the increasing progress in targeted and immune based-directed therapies for other solid organ ...