The glycan masking of the immunodominant BG505-specific 241/289 glycan hole is an established strategy to reduce the otherwise dominant BG505 strain-specific glycan hole-directed NAb responses70,127. In the present study, rabbits vaccinated with SOSIP.664 and TTT immunogens, which did not include...
, PDX models provide the ability to place the same “patient” on all arms of a trial in a given preclinical study. We have developed an extensive cohort of breast cancer PDXs that retain the morphology, cellular heterogeneity, and molecular profiles of the original patient tumors, serving as ...