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GROW-School for Oncology and Developmental Biology, University Maastricht, Maastricht, The Netherlands European Journal of Human Genetics (2010) 18, 265–271; doi:10.1038/ ejhg.2009.109; published online 1 July 2009 *Correspondence: Dr M Otter, Department of Child and Adolescent Psychiatry, Department...
Overall, we provide insights into the biology of TNBC and suggest that caspase-1 plays a pro-tumoral role and contributes to anti-PD1 resistance. TNBC are uniquely capable of IL1β production, with Notch providing IL1β priming and ETS1-dependent caspase-1 expression ensuring IL1β processing...
Breast cancer is a heterogeneous disease that comprises tumour subgroups with substantial differences in biology and clinical behaviour. Classification methods based on the expression of intrinsic genes [1] and on the histological assessment of oestrogen- (ER) and progesterone- (PR) receptor and human...
Li, and the final paper revision is performed by Zhen-yu Wang and Mao-ming Xiong. The data check and quality inspection are performed by Wei-jun Zhang. The experiments are mainly performed by Peng-ping Li, Yu-qing Huang, Ke Sun and Jin-pian Lu. The paper is revised by Peng-ping Li...
XP and XL provided technical and material support; YG and YF wrote the original draft; YG, PL, and JS performed review and revision of the paper. All authors read and approved the final paper. Corresponding authors Correspondence to Yujing Gao, Jingxuan Shan or Pu Li....
\(\begin{array}{l}[a\ b\ c]= \begin{vmatrix}c_{1} & c_{2} & c_{3} \\a_{1} & a_{2} & a_{3} \\b_{1} & b_{2} & b_{3} \\\end{vmatrix}\end{array} \) Properties of Scalar Triple Product: i) If the vectors are cyclically permuted, then ...
The phase 1b LORDSHIPS study has suggested a potentially synergistic anti-tumor effect with pyrotinib, letrozole, and dalpiciclib in front-line patients with HR-positive, HER2-positive metastatic breast cancer15. In this work, we conduct the MUKDEN 01 study to investigate the efficacy and ...
Triple negative breast cancer (TNBC) comprises 15–20% of all invasive breast cancer and is associated with a poor prognosis. As therapy options are limited for this subtype, there is a significant need to identify new targeted approaches for TNBC patien